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STK39 Antibody

  • 货号：
    CSB-PA008880
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9UEW8
  • 基因名：
    STK39
  • 别名：
    DCHT antibody; DKFZp686K05124 antibody; OTTHUMP00000165175 antibody; PASK antibody; Proline alanine rich STE20 related kinase antibody; Serine threonine kinase 39 (STE20/SPS1 homolog yeast) antibody; Serine threonine kinase 39 antibody; Serine/threonine protein kinase 39 antibody; Serine/threonine-protein kinase 39 antibody; Small intestine SPAK like kinase antibody; SPAK antibody; Ste 20 related kinase antibody; Ste-20-related kinase antibody; Ste20 like protein kinase antibody; STE20/SPS1 homolog antibody; STE20/SPS1 related proline alanine rich protein kinase antibody; STE20/SPS1-related proline-alanine-rich protein kinase antibody; STK 39 antibody; Stk39 antibody; STK39_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human SPAK around the non-phosphorylation site of S325.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT.
  • 基因功能参考文献：
    1. SNP rs1468326 of WNK1, rs6749447 of STK39, and WNK1 haplotype AGACAGGAATCGT were associated with hypertension in Tibetan individuals PMID: 28945285
    2. STK39 polymorphisms are not associated with Parkinson's disease, ALS and multiple system atrophy in Chinese population. PMID: 29564728
    3. the polycomb repressor complex is essential for EBNA3A-mediated repression of STK39 Findings in this study provide new insights into the regulation of cellular genes by the transcription factor EBNA3A. PMID: 29367247
    4. STK39 acts as a tumor oncogene in non-small cell type lung cancer and can be a potential biomarker of carcinogenesis. PMID: 27542260
    5. In conclusion, these meta-analytical findings suggest that STK39 might not be a hypertension-susceptibility gene. PMID: 27142475
    6. Here, we report our replication data showing a significant association of the rs3754777 polymorphism, but not rs35929607, of STK39 with essential hypertension in a male Chinese Han population. PMID: 26911228
    7. did not observe any significant difference in allele and genotype distribution between Parkinson's disease patients and controls for rs1955337 in STK39 PMID: 26914237
    8. Single nucleotide polymorphisms STK39 and WNK1 were associated with hypertension and BP in our multicenter Belgian case-control study PMID: 27082544
    9. STK39 mRNA and protein express abnormally in primary hypertension patients with genetic variation, which is related to the blood pressure. PMID: 26662444
    10. SPAK protein has both the potential to up-regulate KCNQ1/E1 protein abundance in the cell membrane, an effect possibly participating in the regulation of cell volume, excitability, epithelial transport and metabolism. PMID: 26584301
    11. These observations establish that the CCT domain plays a crucial role in controlling SPAK activity and BP. PMID: 25994507
    12. Findings indicate that the serine threonine kinase 39 (STK39) mRNA expression is increased in rs3754777 knockin cell lines. PMID: 26416847
    13. These findings suggested that the STK39 rs1955337 TT genotype is a risk factor for Han-Chinese patients with PD in Taiwan PMID: 26469904
    14. Taken together, our findings suggest the potential interactive role of STK39 gene multiple polymorphisms in the development of hypertension among northeastern Han Chinese. PMID: 24873805
    15. In Chinese children, no association of CSK rs1378942, MTHFR rs1801133, CYP17A1 rs1004467, STK39 rs3754777 and FGF5 rs16998073 with BP/risk of hypertension. PMID: 23759979
    16. SPAK short forms in the kidney are created by aspartyl aminopeptidase (Dnpep)-mediated proteolytic cleavage PMID: 25164821
    17. the association of the loci rs11711441 near STK39 and sporadic Parkinson disease in the Chinese Han population is confirmed PMID: 24631562
    18. STK39 (rs2102808) and CCDC62/HIP1R (rs12817488) do not appear to influence PD risk. PMID: 24312176
    19. SPAK isoforms both inhibit NKCC1 and NKCC2 activity (cation cotransporter)that may be important in renal physiology. PMID: 24133122
    20. A significant association between STK39 genetic variant rs6749447 and hypertension was found in a Finnish cohort. PMID: 23235358
    21. Essential hypertension risk conferred by STK39 rs35929607 polymorphism *A/G) was different from that previously reported in a European population. PMID: 23894895
    22. study found no evidence that STK39 was associated with hypertension in the Chinese population PMID: 23151749
    23. The present meta-analysis confirms the significant association of STK39 polymorphism with susceptibility to hypertension in Europeans and East Asians. PMID: 23527223
    24. SPAK and OSR1, which are oftencoexpressed in cells can form functional heterodimers. PMID: 23034389
    25. STK39 is an independent risk factor for hypertension in men and its intragenic single nucleotide polymorphisms can interact and function in the control of blood pressure. PMID: 20889219
    26. our results suggest no significant assocation between any of the core autism symptom domains or the four additional previously identified familial features and the rs1807984 SNP on the STK39 gene. PMID: 21442361
    27. SPAK increases intestinal epithelial permeability; both SPAK-transfected Caco2-cells and SPAK transgenic mice exhibit loss of intestinal barrier function and homeostasis in inflammatory bowel disease. PMID: 21705622
    28. Serine/threonine kinase 39 is a candidate gene for primary hypertension especially in women. PMID: 21178783
    29. phosphorylation-induced activation of NKCC1 by osmotic shrinkage does not involve AMP-activated protein kinase and is likely to be due to STE20/SPS1-related proline/alanine-rich kinase activation PMID: 20442269
    30. STK39 expression is modified by polymorphisms acting in cis and the typed SNPs are associated with allelic expression of this gene, but there is no evidence for an association with blood pressure in a British Caucasian cohort PMID: 20003416
    31. roles in phosphorylation and activation of the Na-K-Cl cotransporter (NKCC1) PMID: 12740379
    32. TNF-related apoptosis-inducing ligand down-regulation of SPAK is an important event that enhances its apoptotic effects PMID: 16950202
    33. evidence for linkage and association between autism and loci within the 2q24-q33 region, including at STK39 PMID: 18348195
    34. PKCdelta acts upstream of SPAK to increase activity of NKCC1 during hyperosmotic stress PMID: 18550547
    35. During inflammatory conditions, TNF-alpha is a key regulator of SPAK expression. PMID: 18787102
    36. variants in STK39 may influence blood pressure by increasing STK39 expression and consequently altering renal Na(+) excretion PMID: 19114657
    37. data suggest that SPAK, the transcription of which is regulated by hyperosmolarity, plays an important role in epithelial barrier function PMID: 19343169
    38. Brain WNK3 acts in tandem with SPAK, whereas renal WNK3 seems to upregulate NCCT through a SPAK-independent pathway. PMID: 19470686
    39. SPAK loss in B-cell lymphomas promotes increased cell survival with DNA damage and provides a potential mechanism for increased resistance to genotoxic stress in cancer. PMID: 19717643

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 组织特异性：
    Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis.
  • 数据库链接：

    HGNC: 17717

    OMIM: 607648

    KEGG: hsa:27347

    STRING: 9606.ENSP00000348278

    UniGene: Hs.276271