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STX3 Antibody

  • 货号：
    CSB-PA613388DSR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA613388DSR1HU at dilution of 1: 100
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA613388DSR1HU at dilution of 1: 100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) STX3 Polyclonal antibody
  • Uniprot No.：
    Q13277
  • 基因名：
  • 别名：
    FLJ30906 antibody; Stx3 antibody; STX3_HUMAN antibody; STX3A antibody; Syntaxin 3A antibody; Syntaxin-3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Syntaxin-3 protein (1-263AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Potentially involved in docking of synaptic vesicles at presynaptic active zones.
  • 基因功能参考文献：
    1. Stx3S is differentially expressed in normal human tissues, during epithelial cell polarization, and in breast cancer versus normal breast tissue. Inhibition of endogenous Stx3S expression alters the expression of cancer-associated genes and promotes cell proliferation. PMID: 29475951
    2. mechanism study shows that STX3 binds to PTEN and increases PTEN ubiquitination and degradation, thus leading to activation of the PI3K-Akt-mTOR signaling. Therefore, STX3 promotes the growth of breast cancer cells by regulating the PTEN-PI3K-Akt-mTOR signaling. PMID: 29408595
    3. we report for the first time a missense mutation of a novel lens specific gene STX3 in a phenotype associating autosomal recessive congenital cataract and intellectual disability. PMID: 25358429
    4. GLUT5 required an interaction cascade of Rab11, Myo5B, Slp4a, Munc18-2, and Vamp7 with Stx3. PMID: 26553929
    5. Rab11a-knockdown cells displayed mislocalization of STX3 and the presentation of microvilli in the basolateral compartment PMID: 25673875
    6. the secretion of IL-1alpha, IL-1beta, IL-12b, and CCL4 occurs during gelatinase degranulation, a process controlled by STX3. PMID: 25548252
    7. The results showed that there was reduction in aggregation propensity of syntaxin-3 with point mutation at Val286. PMID: 25630102
    8. hcmv-miR-US33-5p-mediated inhibition of HCMV DNA synthesis and of viral replication are specifically mediated by down-regulation of STX3 expression. PMID: 25583387
    9. loss of STX3 function causes variant microvillus inclusion disease PMID: 24726755
    10. syntaxin3 has a latent prosurvival function and is involved in maintenance of homeostasis in epidermal keratinocytes PMID: 24171760
    11. In insulin secretion, SYN-3 plays a role in the mediation of newcomer SG exocytosis and SG-SG fusion that contributes to biphasic GSIS. PMID: 23132338
    12. siRNA knockdown (KD) of syntaxins 3 and 4 in HeLa cells reduced cell surface expression of alpha5beta1 and alpha3beta1 integrins PMID: 21720706
    13. STX-3 and SNAP-23 are crucial for the release of all chemokines in mature human mast cells PMID: 21981832
    14. These results demonstrate a function for STX3 in human cytomegalovirus morphogenesis, and unravel a new role for this SNARE protein in late endosomes/lysosomes compartments. PMID: 21371234
    15. syntaxin 3 interacts with CFTR in vivo. PMID: 20844248
    16. Munc18b is functionally coupled to the assembly of exocytic SNARE complexes and increases exocytosis by interacting with the N-peptide and closed-conformation C-terminus of Stx3, thereby neutralizing the secretion-inhibitory effect of this SNARE. PMID: 20695848
    17. Data show that the BCG phagosome is relatively depleted in LAMP-2, NPC1, flotillin-1, vATPase, and syntaxin 3. PMID: 19815536

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  • 亚细胞定位：
    Membrane; Single-pass type IV membrane protein.
  • 蛋白家族：
    Syntaxin family
  • 数据库链接：

    HGNC: 11438

    OMIM: 600876

    KEGG: hsa:6809

    STRING: 9606.ENSP00000338562

    UniGene: Hs.180711