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SUGCT Antibody

  • 货号：
    CSB-PA867183ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: SUGCT antibody at 16μg/ml
      Lane 1: Mouse skeletal muscle tissue
      Lane 2: Mouse liver tissue
      Lane 3: Mouse kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 49, 48, 52, 44 kDa
      Observed band size: 42 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA867183ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA867183ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SUGCT Polyclonal antibody
  • Uniprot No.：
    Q9HAC7
  • 基因名：
    SUGCT
  • 别名：
    SUGCT antibody; C7orf10 antibody; DERP13 antibody; Succinate--hydroxymethylglutarate CoA-transferase antibody; EC 2.8.3.13 antibody; Dermal papilla-derived protein 13 antibody; SuccinylCoA:glutarate-CoA transferase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Succinate--hydroxymethylglutarate CoA-transferase protein (1-250AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate.
  • 基因功能参考文献：
    1. Chromosome microarray analysis showed a 125kb homozygous pathogenic deletion, which includes genes MPLKIP and SUGCT, not described before. This is the first case described in Peru of a novel contiguous gene deletion of Trichothiodystrophy type 4 and Glutaric aciduria type 3 performed by chromosome microarray analysis. PMID: 29421601
    2. C7orf10 encodes succinate-hydroxymethylglutarate CoA-transferase, which is the enzyme that converts glutarate to glutaryl-CoA PMID: 23893049
    3. Identified as a candidate disease gene for OXPHOS disorders by next-generation sequencing PMID: 22277967
    4. Geneic mapping of GA3 to chromosome 7 and identification of mutations in c7orf10 are reported. PMID: 18926513
  • 相关疾病：
    Glutaric aciduria 3 (GA3)
  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    CaiB/BaiF CoA-transferase family
  • 组织特异性：
    Highly expressed in kidney. Intermediate expression in liver, skeletal muscle and pancreas. Little to no expression detected in other tissues examined.
  • 数据库链接：

    HGNC: 16001

    OMIM: 231690

    KEGG: hsa:79783

    UniGene: Hs.586313