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  4. SUGT1 Antibody

SUGT1 Antibody

  • 货号：
    CSB-PA022924GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y2Z0
  • 基因名：
  • 别名：
    Protein 40 6 3 antibody; Protein 40-6-3 antibody; Protein SGT1 homolog antibody; Putative 40 6 3 protein antibody; Sgt1 antibody; SGT1 suppressor of G2 allele of SKP1 antibody; SGT1_HUMAN antibody; SGT1B protein antibody; sugt1 antibody; Suppressor of G2 allele of SKP1 homolog antibody; Suppressor of G2 allele of SKP1 S. cerevisiae homolog of antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SUGT1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.
  • 基因功能参考文献：
    1. the SGT1-HSP90 complex contributes to the E3 ligase activity of the CUL4A complex that is necessary for CENP-A ubiquitylation and CENP-A deposition at the centromere. PMID: 28816574
    2. Data (including data from studies using purified proteins/hepatocyte lysates) suggest eEF1A1/Sgt1a interact as multimer; D2/D3 domains of eEF1A1 and TPR domain of Sgt1 are involved in multimer formation; Sgt1 competes with viral RNA to bind to eEF1A. PMID: 26545799
    3. Data suggest that SspH2 (ubiquitin ligase effector from Salmonella typhimurium) ubiquitination activity and protein stability is enhanced by SGT1. PMID: 23935490
    4. our data revealed a previously uncovered role of SGT1 in gastric cancer development, and suggested that SGT1 could be a promising anti-cancer target to against gastric cancer PMID: 23440515
    5. Chp-1 and melusin can interact with cochaperones PP5 and Sgt1 and with each other in an ATP-dependent manner PMID: 23184943
    6. Plk1 is required for the kinetochore localization of Sgt1 and phosphorylates serine 331 of Sgt1 at the kinetochores. PMID: 22869522
    7. Sgt1 translocates to the nucleus due to heat shock. S100A6 is necessary for nuclear translocation of the Sgt1 protein. PMID: 20213445
    8. S100A6-Ca(2+)-mediated Sgt1 dephosphorylation promotes its nuclear translocation, most likely due to disruption of the Sgt1-Hsp90 complex PMID: 21864708
    9. SUGT1 amplification might give rise to promoting transcription of the gene directly subsequent to the progression of colorectal cancer cases with worsening prognosis PMID: 20126976
    10. These findings support a novel role for Hsp90-Sgt1 chaperones in ensuring the fidelity of Mis12 multiprotein complex assembly. PMID: 20404110
    11. Sgt1 binds to S100A6 in a calcium-regulated manner PMID: 12746458
    12. SGt1.2 is a splicing variant of SGT1 and widely expressed in human adult tissue. PMID: 15346769
    13. Multiple lines of evidence show that SGT1 plays an essential role in signaling pathways linked to Nod1 activation in epithelial lineage cells. PMID: 17420470
    14. This suggests that the interaction of Sgt1 with Hsp70 and Hsp90 is regulated by S100A6 in a Ca(2+)-dependent manner. PMID: 17466273
    15. Sgt1 is a co-chaperone protein with an expression pattern matching that of the well known heat shock proteins. PMID: 18358234
    16. protein kinase CK2 phosphorylates Ser(361) on Sgt1, and this phosphorylation inhibits Sgt1 dimerization PMID: 19398558

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=Translocates to the nucleus upon heat shock, requiring S100A6.
  • 蛋白家族：
    SGT1 family
  • 数据库链接：

    HGNC: 16987

    OMIM: 604098

    KEGG: hsa:10910

    STRING: 9606.ENSP00000367208

    UniGene: Hs.281902