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SULF1 Antibody

  • 货号：
    CSB-PA260604
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA260604(SULF1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q8IWU6
  • 基因名：
    SULF1
  • 别名：
    DSulf antibody; Extracellular sulfatase Sulf 1 antibody; Extracellular sulfatase Sulf-1 antibody; Extracellular sulfatase Sulf1 antibody; HSULF 1 antibody; HSulf-1 antibody; Neu5 antibody; Sulf1 antibody; SULF1_HUMAN antibody; Sulfatase FP antibody; Sulfated antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human SULF1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:10-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.
  • 基因功能参考文献：
    1. High SULF1 expression is associated with glioma. PMID: 29360432
    2. These findings suggested that SULF1 could be an indicator of the clinicopathological features and prognosis of pancreatic cancer. PMID: 29843217
    3. Defective autophagy is associated with loss of HSulf-1 in ovarian cancer. PMID: 28169314
    4. our study found that increased SULF1 expression is significantly predictive of more advanced tumor stage and poorer metastasis-free survival and disease-specific survival in patients with both UTUC and UBUC. PMID: 28525382
    5. Data show that sulfatase 1 (hSulf-1) overexpression in melanoma cells can inhibit cell proliferation and induce cell cycle arrest and apoptosis by decreasing the protein kinase B (AKT) phosphorylation and limiting cyclin dependent kinase 4 (CDK4) nuclear import. PMID: 27806323
    6. Sulf-1 is responsive to TNF-alpha stimulation and may function as an autocrine regulator of fibroblast expansion in the course of an inflammatory response PMID: 27693418
    7. The short variants of Sulf1 promoted FGF2-induced MDA-MB231 and MCF7 in vitro growth while full-length Sulf1 inhibited growth supporting in vivo mammary tumour cell signalling patterns of growth. PMID: 27294358
    8. The SULF1/SULF2 activation thus does not only promote regulated foetal growth and injury-induced liver regeneration but also dysregulated tumour growth. PMID: 27013228
    9. Results show that SULF1 or SULF2 overexpression contributes to colorectal cancer cell proliferation, migration, and invasion. PMID: 25477293
    10. Data suggest that Sulfatase 1 (hSulf-1) may be a suitable target for cancer therapy. PMID: 24970807
    11. findings show an upregulation of SULF1 in degenerative discs for the first time, and suggest that there is a link between SULF1 and disc degeneration PMID: 25469740
    12. rs6990375 polymorphism of SULF1 gene could be one of the factors related to recurrent miscarriage in Iranian women. PMID: 24322345
    13. identification of markers including SULF1 may improve detection of this disease at its earliest stages improving patient treatment and prognosis PMID: 24911625
    14. SULF1/SULF2 splice variants regulate pancreatic tumor progression. PMID: 24726914
    15. Knockdown of SULF2 in human corneal epithelial cell line slowed migration, which was restored by overexpression of either mouse SULF2 or human SULF1. PMID: 23950901
    16. Strong interaction depends on the presence of Sulf1-substrate groups. PMID: 23891937
    17. Ectopic expression of SULF1 or SULF2 in HeLa cells, which decreases cell surface heparan sulfate proteoglycan sulfation, diminished Chlamydia muridarum binding and decreased vacuole formation. PMID: 23480519
    18. these observations provide evidence that HPEI nanogels delivering HSulf-1 combined with DDP may have a promising application in the therapy of human ovarian cancer. PMID: 22825572
    19. miR-21-mediated suppression of both hSulf-1 and PTEN led to activation of AKT/ERK pathways and epithelial-mesenchymal transition in hepatocellular carcinoma, promoting tumor growth. PMID: 23684551
    20. HSulf-1 and HSulf-2 share the same desulfation processs but with a different rate PMID: 23457216
    21. inhibits proliferation and invasion of esophageal squamous cell carcinoma by decreasing heparin-binding growth factor signaling PMID: 23053899
    22. HSULF-1 is expressed at lower levels in H292 lung cancer cells than in normal human alveolar cells and that its over-expression reduced cell viability in H292 cells by inducing apoptotic pathways, at least in part by inhibiting ERK/Akt signaling PMID: 22873647
    23. SULF1 may serve as a promising biomarker for patients with gastric carcinoma. PMID: 22653794
    24. Sulf-1 protein expression is down-regulated in gastric cancer. PMID: 22524839
    25. extracellular HSulf-1 may function as a negative regulator of proliferation and invasion in gastric cancer by suppressing Wnt/beta-catenin signaling at the cell surface. PMID: 21722266
    26. SULF1 and SULF2 are overexpressed in various human cancer types and can be associated to progression and prognosis. PMID: 21599997
    27. Data show that HSulf-1 depletion in breast cancer cells resulted in an increased and sustained bFGF2 (basic fibroblast growth factor) signaling and promoted cell migration and invasion under hypoxic conditions. PMID: 21266348
    28. Phage microarrays containing colorectal cancer cDNA libraries were prepared to identify phage-expressed peptides recognized by tumor-specific autoantibodies from patient sera. PMID: 21228115
    29. Genetic variations in SULF1 may play a role in ovarian cancer onset and prognosis. PMID: 21214932
    30. Haploinsufficiency of SULF1 combined with haploinsufficiency of SLCO5A1 (or the altered expression of a neighboring gene through position effect) could be necessary in the pathogenesis of MSS. PMID: 20602915
    31. The expression levels of four of the up-regulated genes, CXCL1, SPARC, SPP1 and SULF, were significantly higher in the cancerous tissue compared with the normal tissue (fold change 3.4-8.9). PMID: 19780053
    32. Sulfs are extracellular endosulfatases with strong potential for modulating the interactions of heparan sulfate proteoglycans in the extracellular microenvironment PMID: 12368295
    33. modulates signaling by heparin-binding growth factors, and HSulf-1 down-regulation represents a novel mechanism by which cancer cells can enhance growth factor signaling PMID: 12686563
    34. Down-regulation of hSulf1 contributes to hepatocarcinogenesis by enhancing heparin-binding growth factor signaling and resistance to apoptosis. PMID: 14699503
    35. High expression of Hsulf-1 occurs in the stromal elements as well as in the tumor cells in pancreatic cancer and interferes with heparin-binding growth factor signaling PMID: 15817123
    36. HSulf-1 and HSulf-2 have roles in inhibiting myeloma tumor growth PMID: 16192265
    37. Loss of HSulf-1 expression is associated with breast cancer PMID: 17363371
    38. Sulf1 is a TGF-beta1-responsive gene both in vitro and in vivo and may function as a negative regulator of TGF-beta1-induced fibrogenesis PMID: 18503048
    39. Increased sulf-1 expression may change the sulfation patterns of heparan sulfate proteoglycans and growth factor activities and thus contribute to abnormal chondrocyte activation and cartilage degradation in osteoarthritis. PMID: 18507859
    40. Sulf1 and Sulf2 are two heparan sulfate 6-O-endosulfatases that regulate the activity of multiple growth factors, such as fibroblast growth factor and Wnt, and are essential for mammalian development and survival PMID: 18687675
    41. detection of the HSulf-1 promoter methylation in serum samples may have clinical implications in early detection and diagnosis of human breast and gastric cancers. PMID: 19006069
    42. Strategies targeting sulfatase 1(SULF1) or the interaction between SULF1 and the related sulfatase 2 will potentially be important in developing novel cancer therapies. PMID: 19373441
    43. vHNF1 acts as a repressor of HSulf-1 expression and might be a molecular target for ovarian cancer therapy. PMID: 19487294
    44. analysis of the subdomain organization of sulf-1 and sulf-2 PMID: 19520866
    45. Data show that specific regions of the Sulf1 hydrophilic domain (HD) influence different aspects of heparan sulfate binding, cellular localization, and enzyme function. PMID: 19666466
    46. HSulf-1 (SULF1) and HSulf-2 (SULF2) are potent inhibitors of myeloma tumor growth in vivo. PMID: 16192265

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  • 亚细胞定位：
    Endoplasmic reticulum. Golgi apparatus, Golgi stack. Cell surface.
  • 蛋白家族：
    Sulfatase family
  • 组织特异性：
    Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in ovarian carcinoma cell lines, ovarian cancers, brea
  • 数据库链接：

    HGNC: 20391

    OMIM: 610012

    KEGG: hsa:23213

    STRING: 9606.ENSP00000260128

    UniGene: Hs.409602