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SULT2B1 Antibody

  • 货号：
    CSB-PA022943ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Sulfotransferase family cytosolic 2B member 1 antibody at 4μg/ml + MCF-7 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 42, 40 kDa
      Observed band size: 42 kDa
    • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA022943ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA022943ESR2HU at dilution of 1:100
    • Immunoprecipitating SULT2B1 in MCF-7 whole cell lysate
      Lane 1: Rabbit control IgG instead of (1μg) instead of CSB-PA022943ESR2HU in MCF-7 whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
      Lane 2: CSB-PA022943ESR2HU (4μg) + MCF-7 whole cell lysate (500μg)
      Lane 3: MCF-7 whole cell lysate (20μg)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SULT2B1 Polyclonal antibody
  • Uniprot No.：
    O00204
  • 基因名：
    SULT2B1
  • 别名：
    Alcohol sulfotransferase antibody; EC 2.8.2.2 antibody; HSST2 antibody; Hydroxysteroid sulfotransferase 2 antibody; ST2B1 antibody; ST2B1_HUMAN antibody; Sulfotransferase 2B1 antibody; Sulfotransferase family cytosolic 2B member 1 antibody; SULT2B1 antibody; SULT2B1a antibody; SULT2B1b antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Sulfotransferase family cytosolic 2B member 1 protein (1-365AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IP
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IP 1:200-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol. Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA). Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation.; Sulfonates pregnenolone but not cholesterol.
  • 基因功能参考文献：
    1. findings showed clearly the impact of genetic polymorphisms on the cholesterol-sulphating activity of SULT2B1b allozymes, which may underscore the differential metabolism of cholesterol in individuals with different SULT2B1b genotypes PMID: 29701841
    2. Mutation in SULT2B1 leads to an autosomal-recessive congenital ichthyosis phenotype via increased proliferation of human keratinocytes, thickening of epithelial layers, and altered epidermal cholesterol metabolism. PMID: 28575648
    3. Since 1'-hydroxyestragole exposure readily produced DNA injury in B-13/H cells, these data suggest that cholangiocarcinomas generated in rats fed estragole may be dependent, in part, on SULT2B1 activation of the 1'-hydroxyestragole metabolite. PMID: 26739637
    4. Overexpression of SULT2B1b is an independent prognostic indicator and promotes cell growth and invasion in colorectal carcinoma. PMID: 26121319
    5. This study identified specific germline variations in estradiol metabolism-related pathways, namely CYP1B1, SULT2B1, and HSD17B2, as novel prognostic markers that are cumulatively associated with increased risk of prostate cancer progression PMID: 24682418
    6. The SULT2B1 isoforms have a unique 50 amino acid carboxy-terminal sequence that is not present in the other human SULT isoforms (review). PMID: 24020383
    7. Data indicate that cholesterol sulfate (CS) and SULT2B1b inhibited gluconeogenesis by targeting the gluconeogenic factor hepatocyte nuclear factor 4alpha (HNF4alpha) in both cell cultures and human SULT2B1b transgenic mice. PMID: 24277929
    8. SULT2B1 is induced by calcitriol activated vitamin D receptor in human prostate cancer cells. PMID: 23579488
    9. SULT2B1b expression promotes proliferation of hepatocellular carcinoma cells in vitro and in vivo, which may contribute to the progression of HCC. PMID: 23593328
    10. In HT29 cells expression of SULT2B1 was enhanced by probiotic fermentation supernatants without aleurone. PMID: 21840698
    11. The Ca(2+)-bound form may be physiologically relevant for stressed cells with an elevated free calcium level. PMID: 20329768
    12. The expression of SULT2B1b mRNA in endometrial stromal cells is induced by progesterone and that in endometrial epithelial cells is induced by relaxin via the cAMP pathway. PMID: 19243756
    13. alternative splicing of SULT2B1 results in cholesterol sulfotransferase or pregnenolone sulfotransferase PMID: 12145317
    14. crystal structure of hydroxysteroid sulfotransferases SULT2B1a and SULT2B1b bound to the substrate donor product 3'-phosphoadenosine 5'-phosphate and acceptor substrate pregnenolone revealed a different catalytic binding orientation PMID: 12923182
    15. We have documented the presence of the enzyme (SULT2B1b) that sulfonates cholesterol in human platelets and examined the influence of plasma lipoproteins on the expression and activity of this enzyme PMID: 14676143
    16. Differential subcellular localization of SULT2B1b in prostate and placenta suggests that SULT2B1b may be differentially regulated and have different physiological functions in these two hormonally responsive human tissues PMID: 14741047
    17. confinement of SULT2B1b to the granular layer coincides with this being the area with the highest cholesterol sulfate content suggesting that the physiologic action of cholesterol sulfate is likely carried out in this region of the living epidermis PMID: 15140224
    18. Immunohistochemical localization of SULT2B1b in human tissues showed expression in the cytoplasm of ciliated columnar or cuboidal epithelial cells in terminal bronchia. PMID: 15878639
    19. Of five Sp1 elements identified in SULT2B1, two had regulatory activity utilizing immortalized human keratinocytes. PMID: 15953604
    20. SULT2B1b, by acting on a variety of oxysterols, offers a potential pathway for modulating in vivo the injurious effects of these compounds. PMID: 17347498
    21. Results show SULT2B1 polymorpohisms affect enzyme functions. PMID: 17496163
    22. SULT2B1 is involved in reulating prostate cell responsiveness to dehydroepiandrosterone and delta5-androstenediol. PMID: 17626250
    23. Data show that SULT2B1b is localized in cytosol and nuclei of cancerous and normal breast tissue, and that African Americans had significantly more SULT2B1b in nuclei of epithelial cells of normal breast tissue compared to Caucasians. PMID: 18586095

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  • 相关疾病：
    Ichthyosis, congenital, autosomal recessive 14 (ARCI14)
  • 亚细胞定位：
    Cytoplasm, cytosol. Microsome. Nucleus.
  • 蛋白家族：
    Sulfotransferase 1 family
  • 组织特异性：
    Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung.
  • 数据库链接：

    HGNC: 11459

    OMIM: 604125

    KEGG: hsa:6820

    STRING: 9606.ENSP00000201586

    UniGene: Hs.369331