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SUN5 Antibody

  • 货号：
    CSB-PA192614
  • 规格：
    ￥2024
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/70.
    • Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/70.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SUN5 Polyclonal antibody
  • Uniprot No.：
    Q8TC36
  • 基因名：
    SUN5
  • 别名：
    SUN5; SPAG4L; TSARG4; SUN domain-containing protein 5; Sad1 and UNC84 domain-containing protein 5; Sperm-associated antigen 4-like protein; Testis and spermatogenesis-related gene 4 protein
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide corresponding to a region derived from internal residues of Human Sad1 and UNC84 domain containing 5
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope.
  • 基因功能参考文献：
    1. The contribution of SUN5 mutations to acephalic spermatozoa might not be as high as described previously. PMID: 29331481
    2. Results, together with those of the previous study, show that SUN5 is required for the formation of the sperm head-tail junction and male fertility. PMID: 28541472
    3. results demonstrate that biallelic SUN5 mutations cause male infertility due to autosomal-recessive acephalic spermatozoa syndrome PMID: 27640305
    4. SPAG4L may play an important role in the meiotic stage of spermatogenesis PMID: 21711156
  • 相关疾病：
    Spermatogenic failure 16 (SPGF16)
  • 亚细胞定位：
    Nucleus inner membrane; Single-pass membrane protein. Golgi apparatus.
  • 组织特异性：
    Sperm (at protein level). Widely expressed. Conflictingly shown to be specifically expressed in testis.
  • 数据库链接：

    HGNC: 16252

    OMIM: 613942

    KEGG: hsa:140732

    STRING: 9606.ENSP00000348496

    UniGene: Hs.375186