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SUOX Antibody

  • 货号：
    CSB-PA022954HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: SUOX antibody at 2µg/ml + Rat liver tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/15000 dilution
      Predicted band size: 61 kDa
      Observed band size: 61 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA022954HA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA022954HA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SUOX Polyclonal antibody
  • Uniprot No.：
    P51687
  • 基因名：
    SUOX
  • 别名：
    EC 1.8.3.1 antibody; mitochondrial antibody; Sulfite oxidase antibody; Sulfite oxidase mitochondrial antibody; Sulfite oxidase; mitochondrial precursor antibody; Suox antibody; SUOX_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Sulfite oxidase, mitochondrial protein (80-545AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SUOX Antibody (CSB-PA022954HA01HU)，的标记方式是Non-conjugated。对于SUOX Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA022954HB01HU SUOX Antibody, HRP conjugated ELISA
    FITC CSB-PA022954HC01HU SUOX Antibody, FITC conjugated
    Biotin CSB-PA022954HD01HU SUOX Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. SUOX is negatively associated with the progression and proliferation of oral squamous cell carcinoma. PMID: 29280012
    2. This is the first description of the prenatal neurodevelopment of brain disruption in isolated sulfite oxidase deficiency. PMID: 28629418
    3. Novel SUOX mutations were detected in 3 Sulfite oxidase deficiency cases PMID: 27289259
    4. Nitrite binds and reduces at the molybdenum site of mammalian sulfite oxidase, which may be allosterically regulated by heme and molybdenum domain interactions, and contributes to the mammalian nitrate-nitrite-NO signaling pathway in human fibroblasts. PMID: 25314640
    5. This finding suggests the possibility to use oxygen-reactive SO variants in sulfite detoxification, as the loss of SO activity is causing severe neurodegeneration PMID: 26171830
    6. Several mutants of H304 and R309 of SUOX were investigated by steady-state kinetics, laser flash photolysis studies of intramolecular electron transfer (IET), and spectroelectrochemistry. PMID: 24968320
    7. SUOX was decreased and AKR1B10 and CD34 were increased with the stepwise progression of hepatocarcinogenesis. PMID: 23665285
    8. combined genetic association studies in women from China/Netherlands/United States: Data suggest that an SNP in SUOX locus (rs705702) and SNPs in other proteins are associated with polycystic ovary syndrome across ethnic differences. [META-ANALYSIS] PMID: 24106282
    9. effect of mutation of surface residues on the heme domain on intramolecular electron transfer, and steady-state kinetics PMID: 22975842
    10. In this study a human sulfite oxidase variant, in which the active site has been modified to alter substrate specificity and activity from sulfite oxidation to nitrate reduction, is compared to chicken sulfite oxidase. PMID: 22263579
    11. prepared and purified samples of the wild type and various mutants of human SO that are depleted of chloride. These samples do not exhibit the typical lpH EPR spectrum at low pH but rather exhibit spectra that are characteristic of the blocked species PMID: 20491442
    12. Experimental deletions of nonconserved amino acids in the 14-residue interdomain polypeptide tether of sulfite oxidase shorten its length and result in more drastically reduced intramolecular electron transfer rate constants. PMID: 20063894
    13. role of conserved tyrosine 343 in intramolecular electron transfer in this enzyme PMID: 12424234
    14. Sulfite oxidase gene expression in brain and in other tissues. PMID: 12763039
    15. comparison of this structure with other b(5)-type cytochromes reveals distinct structural features present in the sulfite oxidase b(5) domain which promote optimal electron transport between the Moco of sulfite oxidase and the heme of cytochrome c PMID: 12832761
    16. To further assess the role of Arg 160 in human SO, intramolecular electron transfer rates between the reduced heme and oxidized molybdenum centers in the wild type, R160Q, and R160K human SO forms were investigated by laser flash photolysis PMID: 14567685
    17. the Tyr(343) residue is important for both substrate binding and oxidation of sulfite by sulfite oxidase PMID: 14729666
    18. mutation in SUOX gene in sulfite oxidase deficiency PMID: 16140720
    19. mutations to charged residues at the equivalent sites most likely cause crucial global or localized structural changes, and expose an alternative docking site that may compete with the Mo domain for docking of the heme PMID: 16229463
    20. Analysis of recombinant G473D sulfite oxidase indicated that it is severely impaired both in the ability to bind sulfite and in catalysis, with a second-order rate constant 5 orders of magnitude lower than that of the wild type. PMID: 16475804
    21. Magnetic resonance imaging and MR spectroscopy measurements may help differentiate isolated sulfite oxidase deficiency from hypoxic-ischemic condition in patients in whom this diagnosis is not clinically suspected. PMID: 17940249
    22. analysis of protein-protein interaction of sulfite oxidase and cytochrome c catalyzing oxidation of sulfite PMID: 18177044
    23. EPR study of the Mo(V) center of the pathogenic R160Q mutant confirms the presence of three distinct species whose relative abundances depend upon pH. PMID: 18529001
    24. the activity of molybdoenzymes, such as sulfite oxidase, is inhibited by high concentrations of heavy metals in the cell PMID: 18959753

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  • 相关疾病：
    Isolated sulfite oxidase deficiency (ISOD)
  • 亚细胞定位：
    Mitochondrion intermembrane space.
  • 数据库链接：

    HGNC: 11460

    OMIM: 272300

    KEGG: hsa:6821

    STRING: 9606.ENSP00000266971

    UniGene: Hs.558403