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SUSD4 Antibody

  • 货号：
    CSB-PA733164LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA733164LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SUSD4 Polyclonal antibody
  • Uniprot No.：
    Q5VX71
  • 基因名：
    SUSD4
  • 别名：
    SUSD4 antibody; UNQ196/PRO222 antibody; Sushi domain-containing protein 4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Sushi domain-containing protein 4 protein (56-290AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SUSD4 Antibody (CSB-PA733164LA01HU)，的标记方式是Non-conjugated。对于SUSD4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA733164LB01HU SUSD4 Antibody, HRP conjugated ELISA
    FITC CSB-PA733164LC01HU SUSD4 Antibody, FITC conjugated
    Biotin CSB-PA733164LD01HU SUSD4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways.
  • 基因功能参考文献：
    1. SUSD4 expression in both breast cancer cells and T cells infiltrating the tumor-associated stroma is useful to predict better prognosis of breast cancer patients. PMID: 26480818
    2. Membrane-bound isoform SUSD4a inhibits the classical and alternative complement pathways when expressed on the surface of Chinese hamster cells but not when expressed as a soluble, truncated protein. PMID: 23482636
    3. analysis of cloning, expression, refolding, and tissue distribution of Sushi domain-containing protein 4 PMID: 20348246
  • 亚细胞定位：
    [Isoform 1]: Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.
  • 组织特异性：
    Isoform 3 is the predominant isoform in all tissues except cortex, cerebellum, kidney, and breast. Isoform 1 is found primarily in the esophagus and the brain.
  • 数据库链接：

    HGNC: 25470

    OMIM: 615827

    KEGG: hsa:55061

    UniGene: Hs.497841