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  4. SUV39H1 Antibody

SUV39H1 Antibody

  • 货号：
    CSB-PA022972GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O43463
  • 基因名：
    SUV39H1
  • 别名：
    H3 K9 HMTase1 antibody; H3-K9-HMTase 1 antibody; Histone H3-K9 methyltransferase 1 antibody; Histone H3-K9 methyltransferase1 antibody; Histone lysine N methyltransferase, H3 lysine 9 specific 1 antibody; Histone-lysine N-methyltransferase SUV39H1 antibody; KMT1 A antibody; KMT1A antibody; Lysine N methyltransferase 1A antibody; Lysine N-methyltransferase 1A antibody; MG44 antibody; mIS6 antibody; Position-effect variegation 3-9 homolog antibody; Su(var)3 9 homolog 1 antibody; Su(var)3-9 homolog 1 antibody; Suppressor of variegation 3 9 homolog 1 (Drosophila) antibody; Suppressor of variegation 3-9 homolog 1 antibody; SUV39 H1 antibody; SUV39H antibody; SUV39H1 antibody; SUV91_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SUV39H1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.
  • 基因功能参考文献：
    1. unveil E4BP4 as a critical transcriptional modulator repressing RASSF8 expression through histone methyltransferases, G9a and SUV39H1. PMID: 29467226
    2. E-cadherin silencing relies on the formation of a complex between the paRNA and microRNA-guided Argonaute 1 that, together, recruit SUV39H1 and induce repressive chromatin modifications in the gene promoter PMID: 28555645
    3. SUV39H1 dysregulation may be involved in diabetic nephropathy progression, affecting inflammation and apoptosis. PMID: 28852907
    4. KMT1A positively regulated the self-renewal and tumorigenicity of human Bladder cancer stem cells via KMT1A-GATA3-STAT3 circuit, in which KMT1A could be a promising target for bladder cancer therapy. PMID: 28765327
    5. Here, the s demonstrate that chromatin-associated RNA contributes to the stable association of SUV39H1 with constitutive heterochromatin in human cells. PMID: 28760200
    6. Here the s show that Suv39h1 chromodomain binds nucleic acids, and this binding is important for its function in heterochromatin assembly. PMID: 28760201
    7. SirT6 promotes cysteine ubiquitination in the PRE-SET domain of Suv39h1. PMID: 29317652
    8. Our data show that the differential expression of SUV39H1 and SUV39H2 is associated with genomic instability and that the modulation of these HMTases can be an attractive approach to prevent CLL evolution PMID: 28833505
    9. Overexpression of miR-125b and inhibition of its target, SUV39H1, in aging individuals reduces hematopoietic stem cells capacity of B cells generation. PMID: 27304919
    10. KAT7-containing acetyltransferases associating with the Mis18 complex provides competence for histone turnover/exchange activity on alphoid DNA and prevents Suv39h1-mediated heterochromatin invasion into centromeres. PMID: 27270040
    11. Suv39h1 deficiency abrogates stress-dependent upregulation of HP1alpha and gamma, and enhances HP1beta levels. PMID: 28059589
    12. Lysine methyltransferases (KMTs) that mediate methylation marks on histone and non-histone proteins are now recognized as important regulators of gene expression in cycling and non-cycling cells. Among these, the SUV39 sub-family of KMTs. PMID: 28106510
    13. we describe the synthesis of multidomain 'designer chromatin' templates and their application to dissecting the regulation of human Suv39h1 PMID: 26807716
    14. These results suggest a model in which SUV39H1 downregulation promotes the establishment of cellular senescence. PMID: 25063769
    15. CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1/DNMT3A in DNA methylation-based epigenetic silencing PMID: 24292684
    16. PHF2 is likely to repress rDNA transcription by competing with PHF8 for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1. PMID: 25204660
    17. High SUV39H1 expression is associated with hepatocellular carcinoma. PMID: 24844570
    18. Suv39H1 induced apoptosis and inhibited cell proliferation in the gastric cancer MGC803 cell line, while decreasing BCL-2, pro-caspase-9, pro-caspase-3 and C-myc. Suv39H1 may be a potential gene target for anti-gastric carcinoma therapy. PMID: 24737085
    19. SUV39H1 expression was upregulated in glioma cell lines and in glioma tissues compared to normal brain, being positively correlated with grade and histological malignancy. PMID: 23943221
    20. Short-chain fatty acids from periodontal pathogens suppress EZH2, and SUV39H1 to promote Kaposi's sarcoma-associated herpesvirus replication. PMID: 24501407
    21. results suggest that Suv39 h1-H3K9me3 epigenetic repression is involved in BZLF1 transcriptional silencing, providing a molecular basis for understanding the mechanism by which EBV latency is maintained PMID: 24588869
    22. Results suggest that by regulating JMJD2b and SUV39H1 expression, p53 not only controls transcription but also promotes HC relaxation to accelerate a rate-limiting step in the repair of complex genomes. PMID: 23376847
    23. The SUV39H1 chromodomain was shown to recognize histone H3K9me2/3 specifically. PMID: 23285239
    24. SUV39H1 generates a gradient of methylation marks at the kinetochore that provides spatiotemporal information essential for accurate chromosome segregation in mitosis. PMID: 22831836
    25. Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability. PMID: 23509280
    26. Snail interacted with Suv39H1 and recruited it to the E-cadherin promoter for transcriptional repression. PMID: 22562246
    27. Our study demonstrated that SUV39H1 up-regulation contributed to hepatocellular carcinoma development and metastasis. The tumor-suppressive miR-125b served as a negative regulator of SUV39H1. PMID: 22991213
    28. The methylation of Sp1 increased the recruitment of Su(var) 3-9 homologue 1(Suv39H1)to the cyclin B1 promoter, resulting in deacetylation and methylation of histone H3 and subsequent downregulation of cyclin B1. PMID: 22036763
    29. genetic association studies in a Finnish population with type I diabetes: No associations were found between SNPs in SUV39H1 and the diabetic complications studied. PMID: 21896933
    30. findings suggest that Suv39H1 and Suv39H2 are key hypoxia-induced methyltransferases; their decline in fetal lung during late gestation is critical for epigenetic changes resulting in the developmental induction of SP-A PMID: 21402781
    31. RFX1 recruits SUV39H1 to the promoter regions of the CD11a and CD70 genes in CD4(+) T cells, thereby regulating local H3K9 tri-methylation levels. PMID: 21192791
    32. SirT1 preserves heterochromatin structure: it modulates Suv39h1 protein levels in stress conditions by preventing MDM2-mediated polyubiquitination at K87. PMID: 21504832
    33. MDM2 mediates formation of p53-SUV39H1/EHMT1 complex capable of methylating H3-K9 in vitro and on p53 target promoters in vivo. PMID: 20588255
    34. The human SUV39H1 gene is able to partially rescue Su(var)3-9 silencing defects in Drosophila. PMID: 11867540
    35. Suv39h1 enhanced MBD1-mediated transcriptional repression via MBD, not the C-terminal transcriptional repression domain of MBD1. MBD1 links to histone deacetylases through Suv39h1, causing methylation and deacetylation of histones for gene inactivation PMID: 12711603
    36. We investigated occupancy of ER-alpha promoter by pRb2/p130-E2F4/5-HDAC1-SUV39 H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 complexes, and provided a link between pRb2/p130 and chromatin-modifying enzymes in the regulation of ER-alpha transcription PMID: 12789259
    37. SUV39H interacts with Smads and cooperates in BMP-induced repression. PMID: 15107829
    38. Kaposi's Sarcoma-Associated Herpesvirus (KSHV)LANA (Latency-associated nuclear antigen)interacts with SUV39H1 histone methyltransferase, a key component of heterochromatin formation, in KSHV-infected cells PMID: 15220403
    39. The recruitment of SUV39H1 to heterochromatin is at least partly independent from that of HP1 and that HP1 transiently interacts with SUV39H1 at heterochromatin. PMID: 16103223
    40. Interaction between HTLV-1Tax and human SUV39H1 and tethering of SUV39H1 by Tax to the HTLV-1 long terminal repeat PMID: 16409643
    41. permanent transcriptional silencing is mediated by the association of PML-RAR with chromatin-modifying enzymes and by recruitment of the histone methyltransferase SUV39H1, responsible for trimethylation of lysine 9 of histone H3 PMID: 16449642
    42. The association between RUNX1, histone deacetylases and SUV39H1 provides a molecular mechanism for repression and possibly gene silencing mediated by RUNX1. PMID: 16652147
    43. Cabin1 recruits chromatin-modifying enzymes, both histone deacetylases and a histone methyltransferase, to repress myocyte enhancer factor 2 transcriptional activity PMID: 17172641
    44. Suv39H1, HP1gamma and histone H3Lys9 trimethylation play a major role in chromatin-mediated repression of integrated HIV-1 gene expression. PMID: 17245432
    45. SUV39H1 is significantly associated with DNMT1, but not with euchromatic promoter methylation in colorectal cancer PMID: 17657744
    46. Presence of SUV39H1 enhances Evi1 transcriptional repression in a dose dependent manner. PMID: 18619962
    47. Results identify DBC1 as a novel cellular inhibitor of SUV39H1 activity, and suggest that DBC1 may be an important regulator of heterochromatin formation and genomic stability by disrupting the SUV39H1-SirT1 complex and inactivating both enzymes. PMID: 19218236
    48. CTIP2 is a constitutive p21 gene suppressor that cooperates with SUV39H1 and histone methylation to silence the p21 gene transcription. PMID: 19581932

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  • 亚细胞定位：
    Nucleus. Nucleus lamina. Nucleus, nucleoplasm. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, Suvar3-9 subfamily
  • 数据库链接：

    HGNC: 11479

    OMIM: 300254

    KEGG: hsa:6839

    STRING: 9606.ENSP00000365877

    UniGene: Hs.522639