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SYCP3 Antibody

  • 货号：
    CSB-PA004799
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of K562 22RV-1 H460 cells using SCP-3 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q8IZU3
  • 基因名：
  • 别名：
    choline phosphotransferase 1 antibody; chpt1 antibody; COR 1 antibody; COR1 antibody; MGC71888 antibody; RNASCP3 antibody; SCP 3 antibody; SCP-3 antibody; SCP3 antibody; SPGF4 antibody; Sycp 3 antibody; Sycp3 antibody; SYCP3_HUMAN antibody; Synaptonemal complex protein 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human SCP-3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2.
  • 基因功能参考文献：
    1. SCP3 is associated with lymphangiogenesis and provides insight into the SCP3-VEGF-C/VEGF-D axis based cancer therapy strategy. PMID: 28623914
    2. In the model, the reported compaction of chromosomal DNA caused by SYCP3 would result from its ability to bridge distant sites on a DNA molecule with the DNA-binding domains located at each end of its strut-like structure. PMID: 28287952
    3. SYCP3 binds to RAD51 and attenuates RAD51 activity during meiosis. PMID: 28745000
    4. SYCP3 binding and assembly on meiotic chromosomes leads to their organisation into compact structures compatible with recombination and crossover formation PMID: 24950965
    5. The T657C polymorphism of the SYCP3 gene is possibly associated with recurrent pregnancy loss of unknown cause in human. PMID: 25059562
    6. SCP3 plays an important role in the progression of cervical cancer PMID: 24905095
    7. SYCP3 mutations are not associated with the genetic susceptibility for meiotic arrest in infertile male patients with nonobstructive azoospermia in the Turkish population PMID: 22670862
    8. screening for genetic variants in AURKB and SYCP3 among these patients with reproductive problems using Sanger sequencing. Only one apparently non-pathogenic deletion was found in SYCP3. PMID: 23100464
    9. Positive synaptonemal complex protein 3 expression is a portent of poor outcome and may be a potential biomarker in the early stages of the non-small cell lung cancer for survival. PMID: 23069255
    10. mutations in SYCP3 do not contribute significantly to risk for recurrent miscarriage through maternal meiotic nondisjunction. PMID: 22197129
    11. Expression of SYCP3 inhibits the homologous recombination (HR) pathway mediated by RAD51. PMID: 22116401
    12. The 657T>C mutation of SYCP3 may not be associated with recurrent miscarriage caused by aneuploidy. PMID: 21357605
    13. mutation analysis of SYCP3, DNMT3L and MSH4 in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages; heterozygous change, detected in a conserved functional domain of the SYCP3 gene, was absent in >200 controls PMID: 21126912
    14. X-linked lymphocyte-regulated protein pM1 (XMR), XLR, and SCP3 render tumor cells resistant to antitumor immunity PMID: 20395201
    15. We suggest that SYCP3 has an essential meiotic function in human spermatogenesis that is compromised by the mutant protein via dominant negative interference. PMID: 14643120
    16. In contrast to previously reported high frequency of SYCP3 mutations in patients with azoospermia, only polymorphisms are found in the present study PMID: 16213863
    17. SYCP3 is expressed in human testis and is restricted to germ cells. Lack of SYCP3 expression in human testis may have a negative effect on spermatogenesis and male fertility. PMID: 16824523
    18. No functional SYCP3 exonic SNP was found in infertile Spanish patients with meiosis arrest, suggesting that SYCP3 mutations very likely are not relevant in Spain in genetic susceptibility to meiosis arrest. PMID: 17434513
    19. These observations suggest that SCP3 is expressed in adult human and monkey ovaries. PMID: 18256545
    20. mutations in SYPR3 are likely to generate an aberrant synaptonemal complex in a dominant-negative manner and contribute to abnormal chromosomal behavior that might lead to recurrent miscarriage. PMID: 19110213

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  • 相关疾病：
    Spermatogenic failure 4 (SPGF4); Pregnancy loss, recurrent, 4 (RPRGL4)
  • 亚细胞定位：
    Nucleus. Chromosome. Chromosome, centromere.
  • 蛋白家族：
    XLR/SYCP3 family
  • 组织特异性：
    Testis-specific.
  • 数据库链接：

    HGNC: 18130

    OMIM: 270960

    KEGG: hsa:50511

    STRING: 9606.ENSP00000266743

    UniGene: Hs.506504