Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. SYNPO Antibody

SYNPO Antibody

  • 货号：
    CSB-PA023020GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8N3V7
  • 基因名：
    SYNPO
  • 别名：
    KIAA1029 antibody; Synaptopodin antibody; SYNPO antibody; SYNPO_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SYNPO
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity.
  • 基因功能参考文献：
    1. The postsynaptic protein, synaptopodin (SYNPO) was significantly down-regulated in both dementia with Lewy bodies and Parkinson's disease dementia subgroups, suggesting a defective synaptic transmission in the demented patients. PMID: 28800743
    2. Urine synaptopodin is associated with serum creatinine elevation in the patients with glomerulonephritis including diabetic kidney disease regardless of urine albumin excretion. We suggest that the urine synaptopodin level can predict glomerular damage independently of the urine albumin excretion. PMID: 27604800
    3. SYNPO variants are involved in AMPA receptor trafficking and neuronal plasticity, which are associated with cognitive impairment and schizophrenia susceptibility. PMID: 26405221
    4. This study identified and confirmed SYNPO protein changes within the postsynaptic density in schizophrenia PMID: 25048004
    5. Case Report: immunohistologically detected synaptopodin upregulation in foamy podocytes in Fabry disease due to novel alpha-galactosidase A mutation. PMID: 25295576
    6. expression significantly down-regulated in presence of WT1 R458Q mutation PMID: 25145932
    7. Shear stress induced actin binding proteins including SYNPO may play a critical role in endothelial wound healing. PMID: 24561195
    8. These results suggested that the SA is an important component of the molecular machinery controlling the calcium-dependent accumulation of AMPA-receptors (AMPA-R) at excitatory synapses. [review] PMID: 22217474
    9. The urinary mRNA profiles of synaptopodin, podocalyxin, CD2-AP, alpha-actin4, and podocin were found to increase with the progression of diabetic nephropathy. PMID: 21655212
    10. Podocyte BK(Ca) channels are regulated by synaptopodin, Rho, and actin microfilaments. PMID: 20630939
    11. Heterozygous mutations in the promoters of the ACTN4 and SYNPO genes are found in patients with idiopathic focal segmental glomerulosclerosis. PMID: 19666657
    12. interaction with tight junction protein MAGI-1 PMID: 12042308
    13. Our data suggest dendritic spine accumulation of SYNPO critically depends on interaction with postsynaptic alpha-actinin and that SYNPO may regulate spine morphology, motility and function via its distinct modes of association with the actin cytoskeleton. PMID: 15659229
    14. Synaptopodin, an actin-associated protein, as a novel regulator of RhoA signalling and cell migration in kidney podocytes. PMID: 16622418
    15. We conclude that down-regulation of nephrin and synaptopodin is associated with proteinuria in women with preeclampsia. PMID: 17255128
    16. Discusses isoforms of mouse Synpo, two of which are consistent with those found in human. PMID: 15841212

    显示更多

    收起更多

  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell junction, tight junction. Perikaryon. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Cytoplasm, cytosol.
  • 蛋白家族：
    Synaptopodin family
  • 组织特异性：
    Expressed in cerebral cortex.
  • 数据库链接：

    HGNC: 30672

    OMIM: 608155

    KEGG: hsa:11346

    STRING: 9606.ENSP00000377789

    UniGene: Hs.435228