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SZT2 Antibody

  • 货号：
    CSB-PA735962LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA735962LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA735962LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SZT2 Polyclonal antibody
  • Uniprot No.：
    Q5T011
  • 基因名：
    SZT2
  • 别名：
    Chromosome 1 open reading frame 84 antibody; FLJ34502 antibody; Hypothetical protein LOC23334 antibody; Protein SZT2 antibody; RP11-506B15.1 antibody; Seizure threshold 2 homolog A antibody; Seizure threshold 2 protein homolog antibody; SZT2 antibody; SZT2_HUMAN antibody; SZT2A antibody; Uncharacterized protein KIAA0467 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein SZT2 protein (2396-2517AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SZT2 Antibody (CSB-PA735962LA01HU)，的标记方式是Non-conjugated。对于SZT2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA735962LB01HU SZT2 Antibody, HRP conjugated ELISA
    FITC CSB-PA735962LC01HU SZT2 Antibody, FITC conjugated
    Biotin CSB-PA735962LD01HU SZT2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. May play a role in the cellular response to oxidative stress.
  • 基因功能参考文献：
    1. SZT2 has a central role in dictating GATOR-dependent nutrient sensing by promoting lysosomal localization of SZT2-orchestrated GATOR complex, and reveal an unexpected function of lysosome-located GATOR2 in suppressing mTORC1 signalling through SESN recruitment PMID: 28199315
    2. We conclude that the disruption of SZT2 with some residual function might lead to mild or moderate intellectual disability without seizures. PMID: 24324832
    3. mutations in SZT2 cause a severe type of autosomal-recessive infantile encephalopathy. PMID: 23932106
  • 相关疾病：
    Epileptic encephalopathy, early infantile, 18 (EIEE18)
  • 亚细胞定位：
    Lysosome membrane. Peroxisome.
  • 组织特异性：
    Expressed in the brain, predominantly in the parietal and frontal cortex, as well as in dorsal root ganglia. Expressed in peripheral white blood cells.
  • 数据库链接：

    HGNC: 29040

    OMIM: 615463

    KEGG: hsa:23334

    STRING: 9606.ENSP00000457168

    UniGene: Hs.643560