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  4. TAF7 Antibody

TAF7 Antibody

  • 货号：
    CSB-PA023097GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q15545
  • 基因名：
    TAF7
  • 别名：
    RNA polymerase II TBP-associated factor subunit F antibody; TAF 7 antibody; TAF(II)55 antibody; TAF2F antibody; TAF7 antibody; TAF7 RNA polymerase II antibody; TAF7 RNA polymerase II TATA box binding protein (TBP) associated factor 55 kDa antibody; TAF7_HUMAN antibody; TAFII 55 antibody; TAFII-55 antibody; TAFII55 antibody; TATA box binding protein (TBP) associated factor RNA polymerase II F 55kD antibody; TATA box binding protein associated factor 2F antibody; TBP associated factor F antibody; Transcription factor IID subunit TAFII55 antibody; Transcription initiation factor TFIID 55 kDa subunit antibody; Transcription initiation factor TFIID subunit 7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TAF7
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).
  • 基因功能参考文献：
    1. EAF1 (239-268) and TAF7 (205-235) peptide interactions were both mapped to the same groove formed by H3 and H4 helices of MED26 N-terminal domain. PMID: 28893534
    2. the MED26-NTD functions as a molecular switch in the exchange of TBP-associated factor 7 (TAF7) for LEC to facilitate the transition from initiation to elongation during transcription of a subset of snRNA genes PMID: 25575120
    3. These results resolve the structural organization of the TAF1-TAF7 module in TFIID and unveil a critical promoter-binding function of TAF1 in transcription regulation. PMID: 25412659
    4. three CTD kinases, CDK7, CDK9, and BRD4, engage in cross-talk, modulating their subsequent C-terminal domain phosphorylation, and also phosphorylate TAF7 PMID: 23027873
    5. TAF7 represents a novel c-Jun co-activator mediating activation of AP-1 target genes in response to extracellular signals PMID: 12676957
    6. TAF7 has a role as a basal regulator for mammalian polyamine transport activity and MGBG-induced apoptosis PMID: 15078871
    7. Functions as a check-point regulator suppressing premature transcription initiation until preinitiation complex assembly is complete. PMID: 16407123
    8. These results suggest normal TBP-binding interactions--specifically recognition, stability, and conformation-are disrupted by CldAMP insertion into eukaryotic promoter sequences. PMID: 17320040
    9. TAF7 interacts with the transcription factors, TFIIH and P-TEFb, resulting in the inhibition of their Pol II CTD kinase activities PMID: 18391197

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TAF7 family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 11541

    OMIM: 600573

    KEGG: hsa:6879

    STRING: 9606.ENSP00000312709

    UniGene: Hs.438838