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  4. TAF9 Antibody

TAF9 Antibody

  • 货号：
    CSB-PA023100GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q16594
  • 基因名：
    TAF9
  • 别名：
    TAF9 antibody; TAF2G antibody; TAFII31 antibody; Transcription initiation factor TFIID subunit 9 antibody; RNA polymerase II TBP-associated factor subunit G antibody; STAF31/32 antibody; Transcription initiation factor TFIID 31 kDa subunit antibody; TAFII-31 antibody; TAFII31 antibody; Transcription initiation factor TFIID 32 kDa subunit antibody; TAFII-32 antibody; TAFII32 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TAF9
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.
  • 基因功能参考文献：
    1. TAF9 directly binds HCA587/MAGEC2 through its CR domain, suggesting that HCA587/MAGEC2 may involve in TAF9 binding with DNA to regulate certain genes transcription. PMID: 29257297
    2. findings suggest that p53 sequesters TAF9 from GLI1, which may contribute to inhibition of GLI1 activity by p53 PMID: 26282181
    3. TAF9 depletion severely disrupts TFIID, indicating that the observed ongoing transcription is initiated with at least partially TAF-free TATA-binding protein. PMID: 12837753
    4. IL-1-inducible phosphorylation of p65 NFkB is mediated by multiple protein kinases including IKKalpha, IKKbeta, IKKepsilon, TBK1, and an unknown kinase and couples p65 to TAFII31-mediated IL-8 transcription PMID: 15489227
    5. suggest a novel STAF65gamma-dependent function of STAGA-type complexes in cell proliferation and transcription activation by MYC postloading of TFIID and RNA polymerase II that involves direct recruitment of core Mediator PMID: 17967894
    6. TAF9 functionally supports EKLF activity by enhancing its ability to activate the beta-globin gene. TAF9 interacts with a conserved beta-globin downstream promoter element PMID: 19251649
    7. Multiple hTAF(II)31-binding motifs in the intrinsically unfolded transcriptional activation domain of VP16. PMID: 19643037

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TAF9 family
  • 数据库链接：

    HGNC: 11542

    OMIM: 600822

    KEGG: hsa:6880

    STRING: 9606.ENSP00000217893

    UniGene: Hs.653163