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TALDO1 Antibody

  • 货号：
    CSB-PA217736
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA217736(TALDO1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA217736(TALDO1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE,Lysate: 40 μg,Lane 1-6: Mouse kidney tissue, Human kidney tissue, Mouse brain tissue, A431 cells, Human placenta tissue, Human fetal brain tissue,Primary antibody: CSB-PA217736(TALDO1 Antibody) at dilution 1/400 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 10 seconds
  • 其他：

产品详情

  • Uniprot No.：
    P37837
  • 基因名：
    TALDO1
  • 别名：
    Dihydroxyacetone transferase antibody; EC 2.2.1.2 antibody; EPS8L2 antibody; Glycerone transferase antibody; TAL antibody; TAL H antibody; TALDO antibody; TALDO_HUMAN antibody; TALDO1 antibody; TALDOR antibody; TALH antibody; Transaldolase 1 antibody; Transaldolase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human TALDO1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
  • 基因功能参考文献：
    1. These results demonstrate that the nucleocytoplasmic distribution of TALDO1, modulated via alternative translational initiation and dimer formation, plays an important role in a wide range of metabolic networks PMID: 27703206
    2. The above findings support the premise that biallelic mutations in TALDO1 are responsible for transaldolase deficiency and confirm the broad phenotypic variability of this condition, even with the same genotype. PMID: 25388407
    3. This study expands the clinical definition of transaldolase deficiency, and adds to its allelic heterogeneity. PMID: 23315216
    4. Data suggest that exchange reactions during gluconeogenesis catalyzed by transaldolase and triose-phosphate isomerase do not differ between subjects with type 2 diabetes and control subjects under fasting or hyperglycemic conditions. PMID: 23736541
    5. renal phenotype of patients with transaldolase deficiency PMID: 22510381
    6. these data provide strong experimental evidence that transaldolase exchange occurs in humans, resulting in an overestimate of gluconeogenesis PMID: 21062960
    7. Data show that erythronic acid was identified as a major abnormal metabolite in all patients and in knock-out TALDO mice implicating an as yet unknown biochemical pathway in this disease. PMID: 20600873
    8. granzyme B-cleaved transaldolase-specific T cell-mediated cytotoxicity may contribute to the progressive destruction of oligodendrocytes in patients with multiple sclerosis PMID: 20194725
    9. transaldolase is regulated by ZNF143 in a tissue-specific manner PMID: 14702349
    10. TALase undergoes anterograde trafficking in neutrophils from nonpregnant individuals, whereas retrograde trafficking is found during pregnancy PMID: 16092052
    11. Mutation in the TALDO1 gene was found in patients with hydrops fetalis and neonatal multi-organ disease. PMID: 17095351
    12. A patch of functionally important amino acid residues extends from serine-171 toward the catalytic site and is proposed as a novel ligand shuttling path connecting these specific sites to the enzyme's active site. PMID: 17503352
    13. Transaldolase-deficient patients had significantly increased urinary heptoses, revealing novel urinary biomarkers for identification of the deficiency. PMID: 17603756
    14. A new case of TALDO deficiency resulted in cirrhosis, rickets and deafness. PMID: 18331807
    15. The present study identified the TAL deficiency as a modulator of mitochondrial homoeostasis, Ca(2+) fluxing and apoptosis. PMID: 18498245
    16. analysis of enzymes TalB and Taldo1 in human and E. coli PMID: 18687684
    17. genetic polymorphisms in Transaldolase 1 are associated with squamous cell carcinoma of the head and neck . PMID: 18805652

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  • 相关疾病：
    Transaldolase deficiency (TALDOD)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Transaldolase family, Type 1 subfamily
  • 数据库链接：

    HGNC: 11559

    OMIM: 602063

    KEGG: hsa:6888

    STRING: 9606.ENSP00000321259

    UniGene: Hs.438678