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TBL1Y Antibody

  • 货号：
    CSB-PA047135
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA047135(TBL1Y Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA047135(TBL1Y Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9BQ87
  • 基因名：
  • 别名：
    F-box-like/WD repeat-containing protein TBL1Y antibody; TBL1 antibody; TBL1Y antibody; TBL1Y_HUMAN antibody; Transducin (beta) like 1; Y linked antibody; Transducin beta-like 1 antibody; Transducin beta-like protein 1Y antibody; Transducin-beta-like protein 1 antibody; Transducin-beta-like protein 1; Y-linked antibody; Y-linked antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human TBL1Y
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.
  • 基因功能参考文献：
    1. reducing TBL1Y cellular level using siRNA approach influenced cardiac differentiation by reducing its efficacy as well as increasing the probability of impaired contractions; proposed reclassification of TBL1Y as "found missing protein" PMID: 28853286
    2. Our findings suggest that TBL1Y is involved in the genesis of non-syndromic coarctation of the aorta. PMID: 22280357
    3. Taken together,these findings suggest that TBL1 controls NF-kB activation by recruiting NF-kB to its target gene promoter. PMID: 21189284
    4. investigated 12 single-nucleotide polymorphisms in Y-linked neuroligin 4, transducin b-like 1, and eukaryotic translation initiation factor 1a genes, results suggest a Y chromosome effect in autism PMID: 19605777
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    WD repeat EBI family
  • 组织特异性：
    Fetal brain and prostate. Expressed in the cochlear spiral ganglion neurons, and in outer and inner hair cells.
  • 数据库链接：

    HGNC: 18502

    OMIM: 400033

    KEGG: hsa:90665

    STRING: 9606.ENSP00000328879

    UniGene: Hs.664560