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TBL2 Antibody

  • 货号：
    CSB-PA008778
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y4P3
  • 基因名：
    TBL2
  • 别名：
    TBL2 antibody; WBSCR13 antibody; UNQ563/PRO1125Transducin beta-like protein 2 antibody; WS beta-transducin repeats protein antibody; WS-betaTRP antibody; Williams-Beuren syndrome chromosomal region 13 protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human TBL2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. TBL2 participates in ATF4 translation through its association with the mRNA. PMID: 26239904
    2. association of TBL2 with the 60S subunit was ER stress independent while the TBL2-PERK interaction occurred upon ER stress PMID: 25976671
    3. TBL2 interacts with PERK via the N-terminus proximal region and also associates with eIF2a via the WD40 domain thus modulating stress-signaling and cell survival during endoplasmic reticulum stress. PMID: 25393282
    4. A TERE1-TBL2 complex likely functions in oxidative/nitrosative stress, lipid metabolism, and SXR signaling pathways in its role as a tumor suppressor. PMID: 23564352
  • 相关疾病：
    TBL2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of TBL2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
  • 数据库链接：

    HGNC: 11586

    OMIM: 605842

    KEGG: hsa:26608

    STRING: 9606.ENSP00000307260

    UniGene: Hs.647044