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TBX4 Antibody

  • 货号：
    CSB-PA023256LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, HepG2 whole cell lysate
      All lanes: TBX4 antibody at 4.3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 61 kDa
      Observed band size: 61 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TBX4 Polyclonal antibody
  • Uniprot No.：
    P57082
  • 基因名：
    TBX4
  • 别名：
    SPS antibody; T box 4 antibody; T box protein 4 antibody; T box transcription factor TBX 4 antibody; T box transcription factor TBX4 antibody; T-box protein 4 antibody; T-box transcription factor TBX4 antibody; TBX 4 antibody; TBX4 antibody; TBX4_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human T-box transcription factor TBX4 protein (355-511AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TBX4 Antibody (CSB-PA023256LA01HU)，的标记方式是Non-conjugated。对于TBX4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA023256LB01HU TBX4 Antibody, HRP conjugated ELISA
    FITC CSB-PA023256LC01HU TBX4 Antibody, FITC conjugated
    Biotin CSB-PA023256LD01HU TBX4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator that has an essential role in the organogenesis of lungs, pelvis, and hindlimbs.
  • 基因功能参考文献：
    1. We propose phenotypic expansion of the TBX4-related clinical disease spectrum to include acinar dysplasia of the lungs. The reported mutation is the first identified genetic variant causative for acinar dysplasia. PMID: 27374786
    2. TBX4 is a mesenchymal transcription factor that drives accumulation of myofibroblasts and the development of lung fibrosis PMID: 27400124
    3. In a cohort with idiopathic or hereditary pulmonary arterial hypertension, a possibly associated mutation was found in 11.10% of the idiopathic cases (n = 16) and in 68.18% of the hereditary cases. There were 4 mutations found in TBX4. PMID: 27453251
    4. a low level of TBX4 expression suggests a worse prognosis for patients with stage II PDAC. Down-regulation of the TBX4 gene in pancreas is less likely to be regulated by DNA methylation. PMID: 21954337
    5. Although TBX4 remains the candidate gene for congenital clubfoot involving 17q23.1-q23.2 duplications, the explanation for variable expressivity and penetrance remains unknown. PMID: 24592505
    6. data indicate that TBX4 mutations are associated with childhood-onset pulmonary arterial hypertension (PAH), but the prevalence of PAH in adult TBX4 mutation carriers is low PMID: 23592887
    7. Minimal evidence was found for an association between TBX4 and clubfoot and no pathogenic sequence variants were identified in the two known TBX4 hindlimb enhancer elements. PMID: 22678995
    8. Microdeletion of 17q22q23.2 encompassing TBX2 and TBX4 in a patient with congenital microcephaly, thyroid duct cyst, sensorineural hearing loss, and pulmonary hypertension. PMID: 21271665
    9. Mutations in the human TBX4 gene cause small patella syndrome PMID: 15106123

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  • 相关疾病：
    Ischiocoxopodopatellar syndrome (ICPPS)
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 11603

    OMIM: 147891

    KEGG: hsa:9496

    STRING: 9606.ENSP00000240335

    UniGene: Hs.143907