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TCEA3 Antibody

  • 货号：
    CSB-PA023271GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O75764
  • 基因名：
    TCEA3
  • 别名：
    Rhabdomyosarcoma antigen MU RMS 40.22 antibody; Tcea3 antibody; TCEA3_HUMAN antibody; TFIIS antibody; TFIIS.H antibody; Transcription elongation factor A (SII) 3 antibody; Transcription elongation factor A protein 3 antibody; Transcription elongation factor A3 antibody; Transcription elongation factor S-II protein 3 antibody; Transcription elongation factor TFIIS.h antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TCEA3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
  • 基因功能参考文献：
    1. Findings reveal a novel mechanism by which p53 utilizes TFIIS.h to selectively promote the transcriptional elongation of the bax gene, upsurging cell death in response to severe DNA damage. PMID: 27005522
    2. TCEA3 attenuates the proliferation and induces apoptosis of gastric cancer cells PMID: 26498664
    3. Tcea3 binds to TGF-beta I receptor and activates TGF-beta signaling pathway. PMID: 23357533
    4. Study demonstrates a strong synergy between hPAF1C and elongation factor SII/TFIIS and an underlying mechanism involving direct hPAF1C-SII interactions and cooperative binding to RNA polymerase II. PMID: 20178742
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TFS-II family
  • 数据库链接：

    HGNC: 11615

    OMIM: 604128

    KEGG: hsa:6920

    STRING: 9606.ENSP00000406293

    UniGene: Hs.446354