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TCF7 Antibody

  • 货号：
    CSB-PA004247
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Jurkat cells using TCF-1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P36402
  • 基因名：
  • 别名：
    FLJ36364 antibody; MGC47735 antibody; OTTHUMP00000159391 antibody; T cell factor 1 antibody; T cell specific transcription factor 1 antibody; T-cell factor 1 antibody; T-cell-specific transcription factor 1 antibody; TCF-1 antibody; TCF-7 antibody; TCF1 antibody; Tcf7 antibody; TCF7 transcription factor 7 antibody; TCF7_HUMAN antibody; Transcription factor 7 (T cell specific HMG box) antibody; Transcription factor 7 antibody; Transcription factor-7, T-cell specific antibody; Transcription factor-7, T-cell specific, 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human TCF-1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages. Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.
  • 基因功能参考文献：
    1. Our study provides a new mechanism for chromatin occupancy of Tcf7 and uncovers the physiological significance of Uch37 during early vertebrate development by regulating the Wnt/beta-catenin pathway. PMID: 28198400
    2. Results demonstrated that TCF7 expression is upregulated by LOC728196 which operates as the sponge for miR-513c contributing to glioma cell growth and invasion by modulating. PMID: 30179681
    3. LncRNATCF7 overexpression promoted the proliferation and migration of brain neoplasm glioma cells. PMID: 29091867
    4. The results showed SNPs near TCF7 were associated with decreased expression of TCF7 mRNA in PBMCs from patients with SLE and suggested that the mRNA expression of the gene may be correlated with the pathogenesis of SLE. PMID: 28144936
    5. We demonstrated that the AR-miR-1 axis negatively regulates the novel oncogenic factor, TCF7. Dysregulation of TCF7 promoted a survival advantage and resistance to androgen deprivation, suggesting its therapeutic potential for castration-resistant prostate cancer. PMID: 28220803
    6. It promotes invasiveness and self-renewal of human non-small cell lung cancer cells. The potential role of lncTCF7 up regulation in NSCLC metastasis and suggest a promising potential to suppress lncTCF7 for NSCLC patients. PMID: 27766570
    7. High expression of TCF7 is associated with osteosarcoma. PMID: 27683056
    8. Findings indicate that breast cancer cells with a hyperactive AF1q/TCF7/CD44 regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties. PMID: 26079538
    9. TCF7 plays critical roles in lung diseases [review] PMID: 26289446
    10. Tcf7 levels are lower in islets taken from patients with type 2 diabetes. Knockdown of TCF7 in islets impairs the cytoprotective responsiveness to GIP and enhances the magnitude of apoptotic injury. PMID: 26642437
    11. we show that TCF7 is a direct target of miR-34a in prostate cancer that has metastasized to the bone PMID: 25436980
    12. induction of expression activates the Wnt signaling pathway, leading to priming of liver cancer stem cells self-renewal and tumor propagation PMID: 25842979
    13. RUNX2 signaling pathways with their partners TCF7 and FGFR1/2 may not be involved in CCD pathogenesis PMID: 25738174
    14. Results suggest ivermectin as therapeutic WNT protein-TCF transcription factor pathway response blocker to treat WNT-TCF-dependent diseases including multiple cancers. PMID: 25143352
    15. miRNAs inhibited the expression of the luciferase reporter constructs containing 3'UTRs of these genes and downregulated protein expression of TERT and the TCF7 transcription factor, which mediates the canonical Wnt pathway. PMID: 24551047
    16. we establish that ATF2 family members physically and functionally interact with TCF1/LEF1 factors to promote target gene expression and hematopoietic tumor cell growth PMID: 23966864
    17. Studied the expression of TCF/LEF and SFRP family members (SFRP1 and SFRP3) to gain a better understanding of biological signaling pathways responsible for epidemiology and clinical parameters of clear cell RCC (cRCC). PMID: 23572277
    18. in this review, we will focus on the function of beta-catenin/TCF-1 pathway in the regulation of thymic and peripheral T cell differentiation processes--{REVIEW} PMID: 22535304
    19. The repression of syndecan-2 by Wnt/beta-catenin/TCF signaling contributes to the resistance of osteosarcoma cells to doxorubicin. PMID: 22550000
    20. findings show that induction of a dominant negative C-clamp version of TCF1 (dnTCF1E) induces p21 expression and a stall in the growth of DLD1 colon cancer cells; results indicate that a rapid-response WNT/p21 circuit is driven by C-clamp target gene selection PMID: 22778133
    21. Results suggest that Tcf-1 may contribute to pathogenesis of acquired aplastic anemia by regulating downstream gene expression such as c-myc and CD44. PMID: 21881822
    22. In this review we present mounting evidence for the interdependency of TCF7/LEF1 variant expression and functions with cell lineage and cell state. [Review] PMID: 22111711
    23. Findings demonstrate that t-DARPP regulates beta-catenin/TCF activity, thereby implicating a novel oncogenic signaling in upper gastrointestinal cancers. PMID: 21447180
    24. Data show that upon HIPK2-mediated phosphorylation, TCF3 is replaced with positively acting TCF1 at a target promoter. PMID: 21285352
    25. Transgenic T cell factor 1 (TCF1) binds to regulatory regions of the IL17 gene and directly regulates IL17A and IL17F gene expression. PMID: 21339363
    26. TCF7 is involved in genetic risk to Type I Diabetes, although the associations observed for both the intronic SNP rs17653687 and the nonsynonymous change encoded by rs5742913 are relatively modes. PMID: 19956102
    27. beta-catenin and TCF inversely control the expression of the EphB2/EphB3 receptors and their ligand ephrin-B1 in colorectal cancer and along the crypt-villus axis. PMID: 12408869
    28. A polymorphism in ths gene, C883A, is associated with type 1 diabetes. PMID: 12765974
    29. Enforced expression of TCF-1 in transgenic mice yields an expanded Ly-49A subset of natural killer (NK) cells; TCF-1 regulates stable induction of Ly-49A gene expression by formation of a nucleoprotein complex at the Ly-49A promoter. PMID: 12847244
    30. TCF1 is phosphorylated and inhibited by Wnt signal transduction through the Tak1 pathway PMID: 14960582
    31. Ly-49A effectively limits Ag-driven T cell proliferation, cytokine production, and changes in surface receptor expression, and effectively limits Ag-specific CD4 cell responses even in the presence of sustained autoantigen expression in vivo PMID: 15778344
    32. Involvement of transcription factor 7 (T cell factor-1) in the wingless type protein (WNT) signaling pathway not only regulates T cell development, but also peripheral T cell differentiation. PMID: 16424171

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TCF/LEF family
  • 组织特异性：
    Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.
  • 数据库链接：

    HGNC: 11639

    OMIM: 189908

    KEGG: hsa:6932

    STRING: 9606.ENSP00000340347

    UniGene: Hs.573153