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TDRD1 Antibody

  • 货号：
    CSB-PA874834LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA874834LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA874834LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TDRD1 Polyclonal antibody
  • Uniprot No.：
    Q9BXT4
  • 基因名：
    TDRD1
  • 别名：
    Cancer/testis antigen 41.1 antibody; CT41.1 antibody; FLJ21082 antibody; MTR 1 antibody; TDRD 1 antibody; tdrd1 antibody; TDRD1_HUMAN antibody; Tudor domain containing 1 antibody; Tudor domain containing protein 1 antibody; Tudor domain-containing protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Tudor domain-containing protein 1 protein (12-314AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TDRD1 Antibody (CSB-PA874834LA01HU)，的标记方式是Non-conjugated。对于TDRD1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA874834LB01HU TDRD1 Antibody, HRP conjugated ELISA
    FITC CSB-PA874834LC01HU TDRD1 Antibody, FITC conjugated
    Biotin CSB-PA874834LD01HU TDRD1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins.
  • 基因功能参考文献：
    1. TDRD1 protein is expressed in the majority of human prostate tumors, but not in normal prostate tissue. PMID: 27272765
    2. the involvement of TDRD1 genetic polymorphisms in piRNA processing genes in the risk of spermatogenic impairment in a Han Chinese population PMID: 27233649
    3. ERG induces epigenetic activation of Tudor domain-containing protein 1 (TDRD1) in ERG rearrangement-positive prostate cancer. PMID: 23555854
    4. TDRD1 is the first identified upregulated direct ERG target gene that is strongly associated with ERG overexpression in primary prostate cancer PMID: 23319146
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    TDRD1 family
  • 组织特异性：
    Testis and ovary specific. Also expressed in several cancers.
  • 数据库链接：

    HGNC: 11712

    OMIM: 605796

    KEGG: hsa:56165

    STRING: 9606.ENSP00000251864

    UniGene: Hs.333132