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TENT5C Antibody

  • 货号：
    CSB-PA736203LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: TENT5C antibody at 2 μg/ml + Mouse heart tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 45 kDa
      Observed band size: 45, 35 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA736203LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA736203LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FAM46C Polyclonal antibody
  • Uniprot No.：
    Q5VWP2
  • 基因名：
  • 别名：
    FA46C_HUMAN antibody; Fam46c antibody; Family with sequence similarity 46 member C antibody; Protein FAM46C antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Terminal nucleotidyltransferase 5C protein (1-391AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TENT5C Antibody (CSB-PA736203LA01HU)，的标记方式是Non-conjugated。对于TENT5C Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA736203LB01HU TENT5C Antibody, HRP conjugated ELISA
    FITC CSB-PA736203LC01HU TENT5C Antibody, FITC conjugated
    Biotin CSB-PA736203LD01HU TENT5C Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death.; (Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.
  • 基因功能参考文献：
    1. Study shows that FAM46C, a tumor suppressor for hepatocellular carcinoma, is important for the anti-proliferation and proapoptotic effects of norcantharidin. PMID: 28341836
    2. Reduced FAM46C mRNA expression levels were associated with Gastric Cancer. PMID: 27770343
    3. data strengthen the growing evidence that the FAM46C gene is involved in the pathogenesis of MM as a potential tumour suppressor, although its role remains to be clarified. PMID: 26456599
    4. FAM46C is a poly(A) polymerase and that loss of function of FAM46C drives multiple myeloma through the destabilisation of endoplasmic reticulum response transcripts. PMID: 28931820
    5. FAM46C mutation as a contributor to myeloma pathogenesis and disease progression via perturbation in plasma cell differentiation and endoplasmic reticulum homeostasis. PMID: 28619709
    6. Data indicate that when cases with FAM46C deletion or mutation were considered together, they were strongly associated with impaired overall survival (OS) in the intensive treatment setting. PMID: 21994415

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    FAM46 family
  • 数据库链接：

    HGNC: 24712

    OMIM: 613952

    KEGG: hsa:54855

    STRING: 9606.ENSP00000358458

    UniGene: Hs.356216