Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. TERT Antibody

TERT Antibody

  • 中文名称：
    TERT兔多克隆抗体
  • 货号：
    CSB-PA023391LA01DO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Dog TERT Polyclonal antibody
  • Uniprot No.：
    Q6A548
  • 基因名：
  • 别名：
    TERT antibody; Telomerase reverse transcriptase antibody; EC 2.7.7.49 antibody; Telomerase catalytic subunit antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Dog
  • 免疫原：
    Recombinant Dog Telomerase reverse transcriptase protein (1-308AA)
  • 免疫原种属：
    Dog
  • 标记方式：
    Non-conjugated

    本页面中的产品，TERT Antibody (CSB-PA023391LA01DO)，的标记方式是Non-conjugated。对于TERT Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA023391LB01DO TERT Antibody, HRP conjugated ELISA
    FITC CSB-PA023391LC01DO TERT Antibody, FITC conjugated
    Biotin CSB-PA023391LD01DO TERT Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.
  • 基因功能参考文献：
    1. This study evaluated the relationship between polymorphisms of Telomerase Reverse Transcriptase and the longevity and cancer susceptibility of 4 dog breeds. PMID: 24423165
    2. This study reports that the human telomerase promoter operates in canine cells, suggesting that human telomerase promoter-driven cancer therapy can be used to treat cancer in canines. PMID: 21062413
    3. Dog TERT shows the highest level of sequence similarity to the human TERT protein, supporting the dog as a model system for telomerase-based studies. PMID: 15225880
    4. Localization of catalytic subunit of telomerase reverse transcriptase in normal lens epithelial cells(LEC)corresponded with LEC's regional functions. (Catalytic subunit of telomerase reverse transcriptase) PMID: 17093391
    5. A higher expression of TERT was noted in canine and feline meningionas. PMID: 17519562
    6. These findings suggest that telomerase may be a valuable target for canine osteosarcoma (OSA) therapy, and that telomerase status does not appear to be a prognostic factor in canine OSA. PMID: 18761602
    7. DNA sequencing revealed two insertions (175 and 28 bp long) and two deletions (17 and 32 bp long), which were encountered in different combinations and gave rise to five different transcripts. PMID: 18836773
    8. TERT interacted with ERalpha via the estrogen response element (ERE) in cataractous lens epithelial cells (LEC) but not in normal LEC. PMID: 19936027

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Chromosome, telomere. Cytoplasm. Nucleus, PML body.
  • 蛋白家族：
    Reverse transcriptase family, Telomerase subfamily
  • 数据库链接：

    KEGG: cfa:403412

    STRING: 9615.ENSCAFP00000015805

    UniGene: Cfa.114