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TESC Antibody

  • 货号：
    CSB-PA023393HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescent analysis of A549 cells using CSB-PA023393HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western blot
      All lanes: Calcineurin B homologous protein 3 antibody at 2μg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit at 1/10000 dilution
      Predicted band size: 25, 19, 22 kDa
      Observed band size: 25 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TESC Polyclonal antibody
  • Uniprot No.：
    Q96BS2
  • 基因名：
    TESC
  • 别名：
    TESC antibody; CHP3Calcineurin B homologous protein 3 antibody; Tescalcin antibody; TSC antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Calcineurin B homologous protein 3 protein (2-214AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TESC Antibody (CSB-PA023393HA01HU)，的标记方式是Non-conjugated。对于TESC Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA023393HB01HU TESC Antibody, HRP conjugated ELISA
    FITC CSB-PA023393HC01HU TESC Antibody, FITC conjugated
    Biotin CSB-PA023393HD01HU TESC Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
  • 基因功能参考文献：
    1. This study found that the genotype of TESC at the rs7294919 locus and MDD had a significant interactive effect on the hippocampal subfield volume. PMID: 28575645
    2. High Tescalcin expression is associated with colorectal cancer. PMID: 27485112
    3. CHP3 functions as a novel negative regulator of cardiomyocyte hypertrophy via inhibition of GSK3alpha/beta phosphorylation. PMID: 25935310
    4. This study demonstrated that highly significant effects of rs7294919 of tescalcin on hippocampal gray matter volumes. PMID: 24776739
    5. a binding partner and regulator of subunit 4 of the COP9 signalosome PMID: 24659803
    6. TESC is overexpressed in colorectal cancer PMID: 24811141
    7. Loss of both N-myristoylation and calcium binding of CHP3 decreases cell surface stability of NHE1. PMID: 22984264
    8. Tescalcin is one of the key gene products that is involved in switching differentiation program in some cell types. PMID: 20060826
    9. CHP3 binds directly to the proximal juxtamembrane C-terminal region (amino acids 505-571) of rat NHE1 in the same region that binds CHP1 and CHP2. PMID: 18321853

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Membrane; Lipid-anchor. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle membrane.
  • 蛋白家族：
    Calcineurin regulatory subunit family, CHP subfamily
  • 组织特异性：
    Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta.
  • 数据库链接：

    HGNC: 26065

    OMIM: 611585

    KEGG: hsa:54997

    STRING: 9606.ENSP00000334785

    UniGene: Hs.525709