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TESPA1 Antibody

  • 货号：
    CSB-PA012205LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA012205LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA012205LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TESPA1 Polyclonal antibody
  • Uniprot No.：
    A2RU30
  • 基因名：
    TESPA1
  • 别名：
    TESPA1 antibody; KIAA0748 antibody; HSPC257Protein TESPA1 antibody; Thymocyte-expressed positive selection-associated protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein TESPA1 protein (251-521AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TESPA1 Antibody (CSB-PA012205LA01HU)，的标记方式是Non-conjugated。对于TESPA1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA012205LB01HU TESPA1 Antibody, HRP conjugated ELISA
    FITC CSB-PA012205LC01HU TESPA1 Antibody, FITC conjugated
    Biotin CSB-PA012205LD01HU TESPA1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment.
  • 基因功能参考文献：
    1. Tespa1 functions in T cell development and the regulation of TCR-induced Ca(2+) signalling through IP3R1 PMID: 28598420
    2. Tespa1 hay have a role in susceptibility but not severity of rheumatoid arthritis in the Zhejiang Han population in China PMID: 25736038
    3. The TESPA1 gene was found to not be involved in ankylosing spondylitis in a Chinese population. PMID: 24893580
    4. Tespa1 is post-translationally modified upon intracellular divalent calcium-ion Ca2+ increase in thymocytes. PMID: 23541577
    5. Tespa1 is a novel component of mitochondria-associated endoplasmic reticulum membranes and affects mitochondrial calcium flux. PMID: 23501103

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  • 亚细胞定位：
    Cytoplasm. Endoplasmic reticulum membrane.
  • 数据库链接：

    HGNC: 29109

    OMIM: 615664

    KEGG: hsa:9840

    STRING: 9606.ENSP00000312679

    UniGene: Hs.33187