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TET3 Antibody

  • 货号：
    CSB-PA023398LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA023398LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA023398LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TET3 Polyclonal antibody
  • Uniprot No.：
    O43151
  • 基因名：
    TET3
  • 别名：
    hCG_40738 antibody; KIAA0401 antibody; Methylcytosine dioxygenase TET3 antibody; Probable methylcytosine dioxygenase TET3 antibody; Tet methylcytosine dioxygenase 3 antibody; Tet oncogene family member 3 antibody; Tet3 antibody; TET3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Methylcytosine dioxygenase TET3 protein (72-335AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TET3 Antibody (CSB-PA023398LA01HU)，的标记方式是Non-conjugated。对于TET3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA023398LB01HU TET3 Antibody, HRP conjugated ELISA
    FITC CSB-PA023398LC01HU TET3 Antibody, FITC conjugated
    Biotin CSB-PA023398LD01HU TET3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG.
  • 基因功能参考文献：
    1. High mRNA levels of TET3 is independent predictor of poor outcome in Renal Cell Carcinoma patients. PMID: 28069330
    2. TET3 interacts with different members of the thyroid hormone nuclear receptors superfamily and also enhances their association to chromatin. PMID: 28716910
    3. TET3-5-hydroxymethylcytosine was upregulated in the femoral head tissues of SAON patients and MLO-Y4 cells with dexamethasone (Dex) treatment. PMID: 27627619
    4. Results revealed that TET3 acted as a suppressor of ovarian cancer by demethylating miR-30d precursor gene promoter to block TGF-beta1-induced epithelial-mesenchymal transition. PMID: 27141829
    5. TET3 expression inhibits glioblastoma tumorigenesis and self-renewal in glioblastoma stem cells. PMID: 26838672
    6. levels of TET3 and TDG mRNAs were independent prognostic factors for early breast cancer patients who received anthracycline chemotherapy PMID: 26207381
    7. Hypoxia deregulates TET3. TET1/3 levels were associated with tumor hypoxia, tumor malignancy, and poor prognosis in breast cancer patients. Coordinate functions of TET1 and TET3 were needed to activate TNFalpha-p38-MAPK signaling in hypoxia. PMID: 26294212
    8. In hepatic stellate cells, cell proliferation rise significantly and cell apoptosis reduce obviously after knockdown of TET3. PMID: 25550811
    9. OGT catalyzes the O-GlcNAcylation of TET3, promotes TET3 nuclear export, and, consequently, inhibits the formation of 5-hydroxymethylcytosine catalyzed by TET3. PMID: 24394411
    10. TET3 enhanced its localization to chromatin through the stabilization of OGT protein. PMID: 24304661
    11. variable association with CXXC modules may contribute to context specific functions of Tet proteins PMID: 23690950
    12. Studies indicate that the TET-family enzymes are Fe(II), 2-oxoglutarate-dependent oxygenases and catalyze demethylation of 5-methylcytosine (5mC) by iterative oxidation reactions. PMID: 23727577

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Chromosome.
  • 蛋白家族：
    TET family
  • 组织特异性：
    Expressed in colon, muscle, adrenal gland and peripheral blood lymphocytes.
  • 数据库链接：

    HGNC: 28313

    OMIM: 613555

    KEGG: hsa:200424

    STRING: 9606.ENSP00000386869

    UniGene: Hs.516107