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TFAP2E Antibody

  • 货号：
    CSB-PA761516LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: MCF-7 whole cell lysate
      All lanes: TFAP2E antibody at 3.63µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 47 kDa
      Observed band size: 47 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TFAP2E Polyclonal antibody
  • Uniprot No.：
    Q6VUC0
  • 基因名：
    TFAP2E
  • 别名：
    TFAP2ETranscription factor AP-2-epsilon antibody; AP2-epsilon antibody; Activating enhancer-binding protein 2-epsilon antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Transcription factor AP-2-epsilon protein (66-175AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TFAP2E Antibody (CSB-PA761516LA01HU)，的标记方式是Non-conjugated。对于TFAP2E Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA761516LB01HU TFAP2E Antibody, HRP conjugated ELISA
    FITC CSB-PA761516LC01HU TFAP2E Antibody, FITC conjugated
    Biotin CSB-PA761516LD01HU TFAP2E Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation.
  • 基因功能参考文献：
    1. Results showed that lower expression levels of TFAP2E are significantly associated with a shorter survival of patients with neuroblastoma indicating that TFAP2E acts as a tumor suppressor of neuroblastoma. PMID: 28260105
    2. Hypermethylation of TFAP2E was associated with lack of response to fluorouracil-based chemotherapy, indicating that it might be a potential predictor of treatment response in patients with gastric cancer. PMID: 25810491
    3. AP-2E was frequently hypermethylated in tumors from patients with colorectal cancer PMID: 24996990
    4. AP-2epsilon indirectly interacts with the core promoter of COL2A1 and subsequently inhibits its transcriptional activity, thus modulating cartilage development. PMID: 23331625
    5. TFAP2E hypermethylation is associated with clinical nonresponsiveness to chemotherapy in colorectal cancer. PMID: 22216841
    6. These findings reveal that Tfap2 activity, mediated redundantly by Tfap2a and Tfap2e, promotes melanophore differentiation in parallel with Mitf by an effector other than Kit. PMID: 20862309

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    AP-2 family
  • 组织特异性：
    Expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa cell line.
  • 数据库链接：

    HGNC: 30774

    OMIM: 614428

    KEGG: hsa:339488

    STRING: 9606.ENSP00000362332

    UniGene: Hs.567844