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TGM5 Antibody

  • 货号：
    CSB-PA913756
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA913756(TGM5 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA913756(TGM5 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE,Lysate: 40 μg,Lane 1-5: Hela cells, A431 cells, Mouse skin tissue, MCF7 cells, K562 cells,Primary antibody: CSB-PA913756(TGM5 Antibody) at dilution 1/250 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute
  • 其他：

产品详情

  • Uniprot No.：
    O43548
  • 基因名：
    TGM5
  • 别名：
    Protein glutamine gamma glutamyltransferase 5 antibody; Protein-glutamine gamma-glutamyltransferase 5 antibody; PSS2 antibody; TG(X) antibody; TGase 5 antibody; TGase X antibody; TGase-5 antibody; TGase5 antibody; TGASEX antibody; Tgm5 antibody; TGM5_HUMAN antibody; TGM6 antibody; TGMX antibody; TGX antibody; Transglutaminase X antibody; Transglutaminase-5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human TGM5
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.
  • 基因功能参考文献：
    1. Acral PSS (APSS) (OMIM 609796), typically non-inflammatory, is confined to distal extremities with localized exfoliation of the epidermis. It is caused by mutations in the TGM5 gene, encoding transglutaminase 5[3] or in the CTSA gene, encoding cystatin A and it is inherited in autosomal recessive pattern PMID: 25510201
    2. We report both European and non-European families with acral peeling skin syndrome carrying mutations in the TGM5 gene. In 5 patients, we found 3 novel mutations: c.1001+2_1001+3del, c.1171G>A and c.1498C>T. PMID: 25644735
    3. Data trebles the number of TMG5 mutations and provides further evidence that pCly113Cys is a founder mutation in the European population. PMID: 24628291
    4. Genetic variation in the epidermal transglutaminase genes is not associated with atopic dermatitis. PMID: 23189155
    5. TGM5 mutations impact epidermal differentiation in acral peeling skin syndrome. PMID: 22622422
    6. analysis of a recurrent mutation in the TGM5 gene in European patients with acral peeling skin syndrome PMID: 22036214
    7. Acral peeling skin syndrome with TGM5 gene mutations may resemble epidermolysis bullosa simplex in young individuals. PMID: 20164844
    8. transglutaminase 5 contributes, as a secondary effect, to the hyperkeratotic phenotype in ichthyosis (both vulgaris and lamellar) and in psoriasis. PMID: 12230511
    9. Results demonstrate that transglutaminase 5 is able to induce cell death when intracellularly overexpressed. PMID: 15290346
    10. Data show that transglutaminase (TGase) 5 is acetylated at the N-terminal end, is active upon treatment with phorbol acetate, and co-localises with vimentin intermediate filaments. PMID: 15290349
    11. Transglutaminase 5 is expressed during hair follicle homeostasis. PMID: 16117804
    12. A homozygous missense mutation in TGM5 abolishes epidermal TGM5 activity and causes acral peeling skin syndrome. PMID: 16380904
    13. TG5 full-length enzyme has very low enzymatic activity, while the 53-kDa proteolytically processed form is highly active. PMID: 18509357
    14. A missense mutation in TGM5 causes acral peeling skin syndrome in a Tunisian family. PMID: 19440220

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  • 相关疾病：
    Peeling skin syndrome 2 (PSS2)
  • 亚细胞定位：
    Cytoplasm. Note=Associated with intermediate filaments.
  • 蛋白家族：
    Transglutaminase superfamily, Transglutaminase family
  • 组织特异性：
    Expressed in foreskin keratinocytes.
  • 数据库链接：

    HGNC: 11781

    OMIM: 603805

    KEGG: hsa:9333

    STRING: 9606.ENSP00000220420

    UniGene: Hs.129719