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THAP11 Antibody

  • 货号：
    CSB-PA846612LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) THAP11 Polyclonal antibody
  • Uniprot No.：
    Q96EK4
  • 基因名：
    THAP11
  • 别名：
    CTG B43a antibody; CTG B45d antibody; HRIHFB2206 antibody; RONIN antibody; THA11_HUMAN antibody; THAP 11 antibody; THAP domain containing 11 antibody; THAP domain-containing protein 11 antibody; Thap11 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human THAP domain-containing protein 11 protein (1-313AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，THAP11 Antibody (CSB-PA846612LA01HU)，的标记方式是Non-conjugated。对于THAP11 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA846612LB01HU THAP11 Antibody, HRP conjugated ELISA
    FITC CSB-PA846612LC01HU THAP11 Antibody, FITC conjugated
    Biotin CSB-PA846612LD01HU THAP11 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers.
  • 基因功能参考文献：
    1. A transcriptional repressor network including THAP domain containing 11 protein (THAP11) was identified and negatively regulates endogenous PARKIN abundance. PMID: 29269392
    2. We sequenced THAP11 by Sanger sequencing and discovered a potentially pathogenic, homozygous variant in THAP11, c.240C > G (p.Phe80Leu). Further, we provide functional data in model organisms that suggests that both HCFC1 and THAP11 are essential for normal brain development and neural precursor differentiation. PMID: 28449119
    3. the crystal structure of the C-ter region of THAP11 forms a left-handed parallel homo-dimeric coiled-coil structure possessing several unusual features. PMID: 26975212
    4. The M4 motif (ACTAYRNNNCCCR) is a functional regulatory bipartite cis-element, which engages a THAP11/HCF-1 complex via binding to the ACTAYR module, while the CCCRRNRNRC subsequence part constitutes a binding platform for Ikaros and NFKB1 PMID: 27576892
    5. THAP11, ZNF143, and HCF-1 form a mutually dependent complex on chromatin, which is independent of E2F occupancy. PMID: 25437553
    6. that THAP11 reversibly regulated erythroid and megakaryocytic differentiation. PMID: 24637716
    7. HCFC1 is a common component of active human CpG-island promoters and coincides with ZNF143, THAP11, YY1, and GABP transcription factor occupancy. PMID: 23539139
    8. In HCC patients, the expression of THAP11 mRNA significantly correlated with PCBP1 mRNA expression. Our results suggest a novel role of THAP11 in CD44 alternative splicing and hepatoma invasion PMID: 22673507
    9. identify THAP11 as a transcriptional regulator differentially expressed in human colon cancer PMID: 22371484
    10. the induced THAP11 might be one of transcriptional regulators of c-Myc expression in CML cell. PMID: 21400515
    11. Results suggest that THAP11 functions as a cell growth suppressor by negatively regulating the expression of c-Myc. PMID: 19008924

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    THAP11 family
  • 数据库链接：

    HGNC: 23194

    OMIM: 609119

    KEGG: hsa:57215

    STRING: 9606.ENSP00000304689

    UniGene: Hs.632200