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TICAM1 Antibody

  • 货号：
    CSB-PA023532KA01HU
  • 规格：
    ￥2640
  • 图片：
    • Western blot analysis of lung cell lysate using TICAM1 antibody.
  • 其他：

产品详情

  • Uniprot No.：
    Q8IUC6
  • 基因名：
  • 别名：
    TICAM1; PRVTIRB; TRIF; TIR domain-containing adapter molecule 1; TICAM-1; Proline-rich, vinculin and TIR domain-containing protein B; Putative NF-kappa-B-activating protein 502H; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; MyD88-3; TIR domain-containing adapter protein inducing IFN-beta
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Recombinant protein of Human TICAM1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines.
  • 基因功能参考文献：
    1. These data indicate a novel role of the TLR3-TICAM-1 pathway in controlling miR-21 levels in extracellular vesicles. PMID: 29679565
    2. Findings suggest that Toll/IL-1R domain-containing adapter-inducing IFN-beta may be involved in the epileptogenesis of temporal lobe epilepsy, which would make it a potential therapeutic target for the treatment of epilepsy. PMID: 28867282
    3. Data suggest that endosomal localization of TICAM2 is essential for TLR4-mediated type I interferon-inducing signaling from endosomes; TICAM2 acts as scaffold protein and activates TICAM1; N-terminal myristoylation allows TICAM2 to anchor to endosomal membrane. (TICAM2 = toll like receptor adaptor molecule-2; TICAM1 = toll like receptor adaptor molecule-1; TLR4 = toll-like receptor 4) [REVIEW] PMID: 28630139
    4. Data suggest that pro-death signals through TIR-domain-containing adapter-inducing interferon-beta (TRIF) are regulated by autophagy and propose that pro-apoptotic signalling through TRIF/RIPK1/caspase-8 occurs in fibrillary platforms. PMID: 28453927
    5. TRIF gene may contribute to susceptibility of T2DM. PMID: 28479387
    6. The NF-kappaB activated by dsRNA appears not to be the canonical p65/p50 heterodimers. PMID: 28052863
    7. IL-12p70 production requires uptake of Streptococcus pneumoniae as well as the presence of the adaptor molecule TRIF. PMID: 26956584
    8. TIRF high-content imaging system simultaneously showed the expression pattern of EGFRs and EC50 value for CPT-induced apoptosis and necrosis in MCF-7, SK-BR-3 and JIMT-1 cancer cell line PMID: 26886741
    9. involved in signaling that moderates the expression of heme oxygenase1 and il-8 after keratinocytes exposure to dinitrochlorobenzene PMID: 25377948
    10. signaling through TRIF is important for the inflammatory response of AngII-induced abdominal aortic aneurysm formation PMID: 26100679
    11. Data show that toll-like receptor 3/TRIF protein signalling regulates cytokines IL-32 and IFN-beta secretion by activation of receptor-interacting protein-1 (RIP-1) and tumour necrosis factor receptor-associated factor 6 (TRAF6) in cornea epithelial cells. PMID: 25754842
    12. In mice with nonfunctional TRIF (Trif(mut) mice), Ang II-induced hypertension and cardiac hypertrophy were abrogated, and proinflammatory gene expression in heart and kidneys was unchanged or decreased. These results indicate that Ang II induces activation of a proinflammatory innate immune response, causing hypertension and cardiac hypertrophy, which require functional adaptor protein TRIF-mediated pathways. PMID: 26195481
    13. TRIF promotes angiotensin II-induced cross-talk between fibroblasts and macrophages in atrial fibrosis. PMID: 26056004
    14. amino-terminal 21 amino acid sequence is crucial for TRAF3 association, protein stability and activation of the IFN pathway PMID: 24577058
    15. required, in combination with MyD88, for TLR4-mediated proinflammatory dendritic cell differentiation PMID: 23941760
    16. findings show that TRIF activates IRF3 through a phosphorylation-dependent mechanism; results reveal that phosphorylation of innate adaptor proteins is an essential and conserved mechanism that selectively recruits IRF3 to activate the type I IFN pathway PMID: 25636800
    17. PTX3 binds MD-2 and promotes TRIF-dependent immune protection in aspergillosis. PMID: 25049357
    18. MUC1 has a role in regulating epithelial inflammation and apoptosis by PolyI:C through inhibition of TRIF recruitment to Toll-like receptor 3 PMID: 24693944
    19. Enterovirus 68 3C protease cleaves TRIF to attenuate antiviral responses mediated by TLR3. PMID: 24672048
    20. TRIF-N-terminal helical domain shares structural similarity with IFIT5. PMID: 24311583
    21. IL-32-PAR2 axis is an innate immunity sensor providing alternative signaling for LPS-TRIF axis. PMID: 24129891
    22. required for HLA class I antigen presentation during Hantavirus infection PMID: 23824566
    23. Data indicate that TIR domain containing adaptor inducing IFN-beta protein (TRIF), as well as TLR3 activation, enhances Kaposi's sarcoma-associated herpesvirus (KSHV) replication and transcription activator (RTA) protein expression. PMID: 23723066
    24. TRIM38 may act as a novel negative regulator for TLR3-mediated type I interferon signaling by targeting TRIF for degradation PMID: 23056470
    25. ADAM15 acts as a negative regulator of TRIF-mediated NF-kappaB and IFN-beta reporter gene activity via TLR3 and TLR4 signaling. PMID: 23365087
    26. anti-beta(2)GPI/beta(2)GPI complex induced TF and TNF-alpha expression involving both TLR4/MyD88 and TLR4/TRIF signaling pathways and TLR4 and its adaptors might be molecular targets for therapy of antiphospholipid syndrome PMID: 22964479
    27. TICAM1 down-regulation was found to be dependent on TLR3 but not RIG1, MDA5, or PKR and appeared to be regulated post-translationally PMID: 22205631
    28. Data show that The TRIF-selective signaling response resulted in the production of substantially less of the proinflammatory mediators. PMID: 22337809
    29. the D299G polymorphism compromises recruitment of MyD88 and TRIF to TLR4 without affecting TLR4 expression, TLR4-MD2 interaction, or LPS binding, suggesting that it interferes with TLR4 dimerization PMID: 22474023
    30. TRIF may play an important role in the pathogenesis of antiphospholipid syndrome. PMID: 22152804
    31. regulation of the TLR3/TRIF-mediated pathway required the combined action of SHP-1 and SHP-2, which could be accomplished by CD300f but not CD300a PMID: 22043923
    32. The TLR2/4 ligand biglycan enhances antigen-specific T cell priming via MyD88 and Toll-like receptor adapter molecule TRIF pathways, triggering autoimmune perimyocarditis in transgenic mice. PMID: 22095710
    33. Hepatitis A virus inhibits TLR3 signaling by reducing abundance of the adaptor protein TRIF. PMID: 21931545
    34. Susceptibility to herpes simplex encephalitis is caused by TRIF nonsense (autosomal recessive) TRIF deficiency or a missense mutation (autosomal dominant). TRIf is needed for TLR3-dependent interferon synthesis. PMID: 22105173
    35. The host TICAM-1 transgene pathway is essential for antiviral responses that suppress poliovirus infection, which is exacerbated in TICAM-1-deficient poliovirus receptor-bearing mice. PMID: 21998457
    36. show that hBD3 reduces NF-kappaB signaling in cells transfected with MyD88 or TRIF PMID: 21809339
    37. These studies establish that MyD88 but not Trif signaling plays a critical role in mediating cardiac dysfunction, systemic inflammation, and mortality during polymicrobial sepsis PMID: 21792053
    38. PLIC-1 is a novel inhibitor of the TLR3-Trif antiviral pathway by reducing the abundance of Trif PMID: 21695056
    39. TRIF cleavage mediated by human enterovirus 71 3C protease may be a mechanism to impair type I interferon production in response to Toll-like receptor 3 (TLR3) activation. PMID: 21697485
    40. KSHV employs a novel mechanism to block the innate immunity by degrading TRIF protein. PMID: 21212282
    41. TRIF protein induces soluble tumor necrosis factor receptor 1 (TNFR1) shedding via signaling from human airway epithelial cells (NCI-H292) with subsequent activation of two downstream pathways. PMID: 21148036
    42. Silencing TRIF expression reduces TLR5-induced NFkappaB, JNK1/2, and ERK1/2 activation in human colonic epithelial cells. PMID: 20855887
    43. Data show that mutant TICAM-1 failed to recruit the IRF-3 kinase TBK1, resulting in lack of IRF-3 phosphorylation. PMID: 20418377
    44. TRIF modulates TLR5-dependent responses by inducing proteolytic degradation of TLR5 PMID: 20452988
    45. Consistent with results for total tumor necrosis factor (TNF)-alpha messenger RNA (mRNA) levels, lipopolysaccharide-stimulated Trif transgenic and wild-type bone marrow-derived dendritic cells generate comparable amounts of TNF-alpha transcripts. PMID: 20375303
    46. SARM-mediated inhibition may not be exclusively directed at TRIF or MyD88, but that SARM may also directly inhibit MAPK phosphorylation PMID: 20306472
    47. TRIS was associated with TRIF upon TLR3 activation by poly(I-C). These findings reveal an unexpected mechanism of TLR3-mediated signaling. PMID: 20200155
    48. The binding of TRAF2 and TRAF6 to TICAM-1 cooperatively activates the IFN-inducing pathway through ubiquitination of TICAM-1. PMID: 20047764
    49. TRIF is identified and characterized as a novel adaptor protein containing the Toll/IL-1 receptor domain, with a specific role in TLR3 signaling. PMID: 12471095
    50. identified an alternative adaptor, designated Toll-interleukin 1 receptor domain (TIR)-containing adaptor molecule (TICAM)-1, that can physically bind the TIR domain of TLR3 PMID: 12539043

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  • 相关疾病：
    Herpes simplex encephalitis 4 (HSE4)
  • 亚细胞定位：
    Cytoplasmic vesicle, autophagosome. Cytoplasm, cytosol. Mitochondrion.
  • 组织特异性：
    Ubiquitously expressed but with higher levels in liver.
  • 数据库链接：

    HGNC: 18348

    OMIM: 607601

    KEGG: hsa:148022

    STRING: 9606.ENSP00000248244

    UniGene: Hs.29344