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TIMM23 Antibody

  • 货号：
    CSB-PA023553ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: TIMM23 antibody at 3.03µg/ml
      Lane 1: Rat heart tissue
      Lane 2: Mouse liver tissue
      Lane 3: A431 whole cell lysate
      Lane 4: MCF-7 whole cell lysate
      Lane 5: Jurkat whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 22 kDa
      Observed band size: 22 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA023553ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA023553ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品描述：

    The rabbit was immunized with recombinant human TIMM23 protein (1-209aa) to produce the TIMM23 polyclonal antibody, which is an IgG isoform and exhibits a liquid form. Antigen affinity purification was used to purify this antibody. This TIMM23 antibody shows reactivity with the TIMM23 protein from human, mouse, and rat species.

    This TIMM23 polyclonal antibody has been validated to recognize the TIMM23 protein in ELISA, WB, and IHC assays. TIMM23 is an essential protein found in the mitochondrial inner membrane, which is involved in the translocation of preproteins into mitochondria. Therefore, this TIMM23 polyclonal antibody may be utilized to investigate the function and localization of the TIMM23 protein and its role in mitochondrial protein import.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TIMM23 Polyclonal antibody
  • Uniprot No.：
    O14925
  • 基因名：
    TIMM23
  • 别名：
    TIMM23 antibody; TIM23 antibody; Mitochondrial import inner membrane translocase subunit Tim23 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Mitochondrial import inner membrane translocase subunit Tim23 protein (1-209AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
  • 基因功能参考文献：
    1. Data indicate the essential role of the GABP transcription factor in activating translocase of inner mitochondrial membrane 23 TIMM23 and TIMM23B expression. PMID: 29413900
    2. The interaction of presequence peptides with Tim23 intermembrane space domain is weakened in presence of Ca2+ ion, which implicates that Ca2+ ion may play an important role in the protein import by TIM23 complex. PMID: 27178215
    3. Modulating the sorting of nuclear-encoded proteins into mitochondria, mediated by the TIM23 complex, proves therapeutic in both yeast and patient-derived cells exhibiting ATP synthase deficiency. PMID: 25519239
    4. Three distinct Tim23 complexes, namely, B1, B2, and A, are involved in the maintenance of normal mitochondrial function. PMID: 24636990
    5. GST pull-down experiments and tryptophan fluorescence indicated that there is no interaction between Tim23IMS and Tim50IMS PMID: 23811401
    6. MCJ functions as J co-chaperone of the human TIM23 pre-protein translocase. PMID: 23263864
    7. Study establishes an unexpected molecular link between the TIM23 transport machinery and assembly of respiratory-chain complexes that regulate mitochondrial protein synthesis in response to their assembly state. PMID: 23260140
    8. The non-bound hydrophilic domain of the human Tim23 is in a molten globule configuration with marginal stability, existing as a dimer. PMID: 22306744

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  • 亚细胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Tim17/Tim22/Tim23 family
  • 数据库链接：

    HGNC: 17312

    OMIM: 605034

    KEGG: hsa:100287932

    STRING: 9606.ENSP00000260867

    UniGene: Hs.524308