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TIMMDC1 Antibody

  • 货号：
    CSB-PA885685LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: A375 whole cell lysate, Mouse heart tissue
      All lanes: TIMMDC1 antibody at 2.9μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 33 kDa
      Observed band size: 33 kDa
    • IHC image of CSB-PA885685LA01HU diluted at 1:100 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TIMMDC1 Polyclonal antibody
  • Uniprot No.：
    Q9NPL8
  • 基因名：
    TIMMDC1
  • 别名：
    TIMMDC1; C3orf1; UNQ247/PRO284; Complex I assembly factor TIMMDC1, mitochondrial; Protein M5-14; Translocase of inner mitochondrial membrane domain-containing protein 1; TIMM domain containing-protein 1
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase UHRF2 protein (1-71AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TIMMDC1 Antibody (CSB-PA885685LA01HU)，的标记方式是Non-conjugated。对于TIMMDC1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA885685LB01HU TIMMDC1 Antibody, HRP conjugated ELISA
    FITC CSB-PA885685LC01HU TIMMDC1 Antibody, FITC conjugated
    Biotin CSB-PA885685LD01HU TIMMDC1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I.
  • 基因功能参考文献：
    1. Cell-cycle arrest genes such as CCNG2 and PTEN as well as genes involved in cell migration inhibition, such as TIMP3 and COL3A1, were upregulated after C3orf1 depletion in 95D cells. PMID: 25391042
    2. Quantitative proteomics demonstrated a role for TIMMDC1 in assembly of membrane-embedded and soluble arms of the complex. PMID: 24344204
  • 亚细胞定位：
    Mitochondrion membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Tim17/Tim22/Tim23 family
  • 组织特异性：
    Generalized expression enhanced in heart and skeletal muscle.
  • 数据库链接：

    HGNC: 1321

    OMIM: 615534

    KEGG: hsa:51300

    STRING: 9606.ENSP00000418803

    UniGene: Hs.477287