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  4. TJP2 Antibody

TJP2 Antibody

  • 货号：
    CSB-PA080000
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9UDY2
  • 基因名：
    TJP2
  • 别名：
    C9DUPq21.11 antibody; DFNA51 antibody; DUP9q21.11 antibody; Friedreich ataxia region gene X104 (tight junction protein ZO-2) antibody; MGC26306 antibody; PFIC4 antibody; Tight junction protein 2 antibody; Tight junction protein ZO 2 antibody; Tight junction protein ZO-2 antibody; TJP2 antibody; X104 antibody; ZO 2 antibody; ZO-2 antibody; ZO2 antibody; ZO2_HUMAN antibody; Zona occludens 2 antibody; Zona occludens protein 2 antibody; Zonula occludens protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human ZO-2 around the non-phosphorylation site of Y1118.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in tight junctions and adherens junctions.
  • 基因功能参考文献：
    1. Biochemistry and microscopy approaches in T cells confirmed SNX27/ZO-2 PDZ-dependent interaction, and demonstrated its role controlling the dynamic localization of ZO-2 at the IS PMID: 28477369
    2. A likely causal mutation was identified in the majority (61%), spanning many genes including ones that have only rarely been reported to cause cholestatic liver disease, e.g. TJP2 and VIPAS39 PMID: 28039895
    3. Studies indicate the modular and supramodular organization of zonula occludens protein 2 (ZO-2) that allows it to interact with a wide variety of molecules, including cell-cell adhesion proteins, cytoskeletal components, and nuclear factors. PMID: 28415133
    4. Data identified two Disease-causing Genes TJP2 and GJB2 in a Chinese Family with Unconditional Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment. PMID: 26668150
    5. TJP2 deficiency may predispose to hepatocellular carcinoma in early childhood PMID: 25921221
    6. Claudin-19, the most abundant claudin in myelin, exhibited no binding to ZO2. PMID: 25712527
    7. JAM-A regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and control contraction of the apical cytoskeleton. PMID: 23885123
    8. Protein-truncating mutations in the tight junction protein 2 gene cause failure of protein localization and disruption of tight-junction structure, leading to severe cholestatic liver disease. PMID: 24614073
    9. demonstrated that ZO-2 inhibition increases invasive and migrative capacities of invasive tumor cells. This was associated with an increase of MT1-MMP PMID: 23605953
    10. the Alu-related transcript of TJP2 gene (TJP2-Alu transcript) was differentially expressed between colorectal tumor and normal tissues; potential diagnostic markers for colorectal cancer. PMID: 23612256
    11. ZO-2 inhibits the Wnt signaling pathway, reduces cell proliferation, and promotes apoptosis; its absence, mutation, or overexpression is present in various human diseases, including deafness and cancer. PMID: 22671599
    12. AmotL1 and ZO-2 are two candidates that could be harnessed to control the oncogenic function of YAP. PMID: 21685940
    13. these findings imply involvement of the ZO-2 tight junction independent signaling complex containing Jak1 and uPAR in VSMC intercellular communications. PMID: 21679692
    14. ZO-2 interacts with YAP2 to form complex; ZO-2 facilitates both nuclear translocation of YAP2 & pro-apoptotic function of YAP2; YAP2/ZO-2 complex appears to be involved in cell detachment PMID: 20868367
    15. The identification of ZASP helps to unfold the complex nuclear molecular arrays that form on ZO-2 scaffolds. PMID: 20868680
    16. the first PDZ domain of zona occludens-1 (ZO-1) and 2 (ZO-2) interacts with the carboxy-terminal PDZ binding motif of TAZ PMID: 20850437
    17. TJP2- and GSK-3beta-mediated increased susceptibility to apoptosis of cells of the inner ear is the mechanism for adult-onset hearing loss in this kindred and may serve as one model for age-related hearing loss in the general population. PMID: 20602916
    18. Study shows that ZO isoforms bind PtdInsPs and offers an alternative regulatory mechanism for the formation and stabilisation of protein complexes in the nucleus. PMID: 19784548
    19. Familial hypercholanemia in Amish individuals is associated with mutations in tight junction protein 2 (encoded by TJP2, also known as ZO-2) and bile acid Coenzyme A: amino acid N-acyltransferase (encoded by BAAT). PMID: 12704386
    20. Sertoli cells associated with carcinoma in situ of the testicles show an altered distribution of ZO-2 and loss of blood-testis barrier function. PMID: 17217619
    21. TJP2 did not reveal a otosclerosis-causing mutation PMID: 18224337
    22. upregulation of ZO-2 by Angiopoietin-1 which reduces vascular endothelial growth factor-induced brain endothelial permeability PMID: 19148554
    23. Structural comparison shows that the ZO-2 PDZ2 homodimer may have a similar ligand-binding pattern to the ZO-1 PDZ2-connexin 43 complex. PMID: 19342771
    24. The tight junction protein ZO-2 is involved in regulation of vascular smooth muscle cells growth control upon vascular injury that is mediated by the transcription factor Stat1. PMID: 19380416
    25. ZO-2 may serve to anchor regulatory proteins at gap junctions composed of Cx36. PMID: 19418635

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  • 相关疾病：
    Familial hypercholanemia (FHCA); Cholestasis, progressive familial intrahepatic, 4 (PFIC4)
  • 亚细胞定位：
    Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Nucleus.
  • 蛋白家族：
    MAGUK family
  • 组织特异性：
    This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, he
  • 数据库链接：

    HGNC: 11828

    OMIM: 607709

    KEGG: hsa:9414

    STRING: 9606.ENSP00000438262

    UniGene: Hs.50382