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TLK2 Antibody

  • 货号：
    CSB-PA801231LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA801231LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA801231LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA801231LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TLK2 Polyclonal antibody
  • Uniprot No.：
    Q86UE8
  • 基因名：
    TLK2
  • 别名：
    MGC44450 antibody; PKU alpha antibody; PKU-alpha antibody; Serine/threonine kinase antibody; Serine/threonine protein kinase tousled like 2 antibody; Serine/threonine-protein kinase tousled-like 2 antibody; TLK 2 antibody; tlk2 antibody; TLK2_HUMAN antibody; Tousled like kinase 2 antibody; Tousled-like kinase 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Serine/threonine-protein kinase tousled-like 2 protein (23-234AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TLK2 Antibody (CSB-PA801231LA01HU)，的标记方式是Non-conjugated。对于TLK2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA801231LB01HU TLK2 Antibody, HRP conjugated ELISA
    FITC CSB-PA801231LC01HU TLK2 Antibody, FITC conjugated
    Biotin CSB-PA801231LD01HU TLK2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.
  • 基因功能参考文献：
    1. haploinsufficiency of TLK2 is the most likely underlying disease mechanism, leading to a consistent neurodevelopmental phenotype. PMID: 29861108
    2. Molecular basis of TLK2 activation and inhibition has been dissected. PMID: 29955062
    3. TLK2 is amplified in aggressive luminal breast neoplasms PMID: 27694828
    4. Tlk2 promotes Asf1A function during the DNA damage response in G2 to allow for proper restoration of chromatin structure at the break site and subsequent recovery from the arrest. PMID: 26931568
    5. Results show that TLK2 overexpression correlates with increased genome-wide copy number aberrations in breast cancer cells, impairs cell-cycle checkpoint signaling in response to DNA damage. PMID: 27489360
    6. TLK2 plays a role in Kaposi's sarcoma-associated herpesvirus reactivation. PMID: 23414760
    7. TLKs appear to be intimately linked to the pattern of resistance to DNA damage, and specifically double-strand breaks. PMID: 21647934
    8. ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a by TLK kinases. PMID: 20016786

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  • 亚细胞定位：
    Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family
  • 组织特异性：
    Ubiquitous. Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle. Highly expressed in testis. Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral blood leukocytes.
  • 数据库链接：

    HGNC: 11842

    OMIM: 608439

    KEGG: hsa:11011

    STRING: 9606.ENSP00000275780

    UniGene: Hs.445078