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TLL1 Antibody

  • 货号：
    CSB-PA023595LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA023595LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA023595LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA023595LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TLL1 Polyclonal antibody
  • Uniprot No.：
    O43897
  • 基因名：
    TLL1
  • 别名：
    ASD6 antibody; TLL antibody; TLL1 antibody; TLL1_HUMAN antibody; Tolloid like 1 antibody; Tolloid-like protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Tolloid-like protein 1 protein (522-643AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TLL1 Antibody (CSB-PA023595LA01HU)，的标记方式是Non-conjugated。对于TLL1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA023595LB01HU TLL1 Antibody, HRP conjugated ELISA
    FITC CSB-PA023595LC01HU TLL1 Antibody, FITC conjugated
    Biotin CSB-PA023595LD01HU TLL1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
  • 基因功能参考文献：
    1. Multivariate analysis showed rs17047200 AT/TT to be an independent risk factor for HCC (hazard ratio, 1.78; P = .008). PMID: 28163062
    2. This SNP [TLL1 gene ]could not be confirmed as a risk factor for CHD [coronary heart disease]in T2DM [type-2 Diabetes mellitus]patients PMID: 25233961
    3. This study identified TLL1 as a new susceptibility gene for PTSD. PMID: 23726511
    4. TLL-1 gene mutation with an insertion mutation of base A in exon 10 is common in Chinese patients with sporadic congenital heart diseases. PMID: 22883091
    5. We identified a variant in a single PPAR pathway gene, TLL1, that is associated with the extent of coronary artery disease independently of clinical predictors, specifically in patients with type 2 diabetes mellitus. PMID: 21911782
    6. Data demonstrate that TLL-1, which has intermediate activity, forms a calcium-ion dependent dimer with monomers stacked side-by-side. PMID: 20043912
    7. tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains PMID: 16507574
    8. The crystal structures of the protease domains of human BMP-1 and the closely related Tolloid-like protease 1 (TLL-1), are reported. PMID: 18824173
    9. Mutations in mammalian tolloid-like 1 gene detected in adult patients with Atrial septal defect PMID: 18830233
    10. These results indicate that the hypoxia responsive motif is directly involved in the activation of the mTll-1 transcription under hypoxic conditions. PMID: 19723501

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  • 相关疾病：
    Atrial septal defect 6 (ASD6)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase M12A family
  • 数据库链接：

    HGNC: 11843

    OMIM: 606742

    KEGG: hsa:7092

    STRING: 9606.ENSP00000061240

    UniGene: Hs.106513