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  4. TLR1 Antibody

TLR1 Antibody

  • 货号：
    CSB-PA953581
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA953581(TLR1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA953581(TLR1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse thymus tissue, K562 cells, Primary antibody: CSB-PA953581(TLR1 Antibody) at dilution 1/175, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q15399
  • 基因名：
  • 别名：
    CD281 antibody; CD281 antigen antibody; KIAA0012 antibody; LPRS5 antibody; rsc786 antibody; TIL antibody; TIL. LPRS5 antibody; Tlr1 antibody; TLR1_HUMAN antibody; Toll (Drosophila) homolog antibody; Toll like receptor 1 antibody; Toll-like receptor 1 antibody; Toll/interleukin-1 receptor-like protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human TLR1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:15-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
  • 基因功能参考文献：
    1. mean proportions of European ancestry differed significantly between the genotypes of the TLR6 (P249S) gene in a population of the Atlantic Forest, Sao Paulo, Brazil PMID: 29175392
    2. rs5743618 polymorphism increased the the risk of needing inhaled corticosteroids at 11-13 years of age for postbronchiolitis asthma PMID: 28692144
    3. Suggest that the TLR1 rs4833095 polymorphism may play a role in the development and progression of IgA nephropathy in a Chinese Han population. PMID: 27806314
    4. genetic polymorphism is associated with transplant-related mortality in hematologic malignancies PMID: 27369862
    5. Significant correlations with atherosclerosis susceptibility were found for the toll like receptor 1 (TLR1) rs5743551 polymorphism and toll like receptor 6 (TLR6) rs5743810 polymorphism. PMID: 28474755
    6. Study concludes that genetic variation in the TLR10-TLR1-TLR6 gene cluster mediates responsiveness to organic dust, but indicates different signaling pathways for IL-6 and TNF-alpha. These studies provide new insight into the role of the TLR10-TLR1-TLR6 gene cluster and the innate immune response to organic dust. PMID: 28123183
    7. data indicates that different TLR genes may actually play a role in the IL-17 production. In addition, different markers of TLR1, 2 and 4 appeared associated with serum levels of other important cytokines and chemokines that take part in the leprosy pathogenesis PMID: 28327786
    8. Association analyses yielded a significant result for the TLR1 variant rs3923647, conferring strong protection against Tuberculosis (Odds ratio [OR] 0.21, CI confidence interval [CI] 0.05-0.6, Pnominal 1 x 10-3) when applying a recessive model of inheritance. PMID: 27214039
    9. Our data suggest that TLR1 rs5743618 could serve as a predictor of clinical response to FOLFIRI plus bevacizumab in patients with mCRC. PMID: 27196764
    10. rs5743551 and rs5743618 polymorphisms affected the risk of pulmonary tuberculosis in an Iranian population PMID: 27998389
    11. Studied the relationship between polymorphisms in MBL, TLR1, TLR2 and TLR6 encoding genes and stimulated IFN-gamma and IL-12 ex vivo production in BCG osteitis survivors. Found that variant genotypes of the MBL2 gene (if homozygous) and variant genotypes of the TLR2 gene (only heterozygotes present) are associated with low IFN-gamma production. PMID: 27755461
    12. 2 single nucleotide polymorphisms in toll like receptor 1 were significantly associated with Treponema denticola. PMID: 27727278
    13. We found lower expression levels of TLR1, TLR3, TLR4, TLR7 and TLR9 in PBMCs from patients with ALL compared with those from control patients. We also observed that the PBMCs from patients with Pre-B and B ALL had lower TLR4 expression than controls PMID: 27277333
    14. These data suggest that the TLR1 N248S polymorphism might play a role in Th1/Th2 differentiation, and the determination of serum IgE levels. PMID: 25825356
    15. a case-control study of 504 Papua New Guinean children with severe malaria showed that a genetic variant in TLR1 may contribute to the low severe malaria case fatality rates in this region through a reduced pro-inflammatory cellular phenotype. PMID: 26633000
    16. The data suggest that genetic variation in TLR1 has effects on the host response to Plasmodium falciparum malaria in Asian populations. PMID: 26738805
    17. a novel mechanism of action for TLR1 SNP rs5743618 in modulating polymorphonuclear leukocytes priming responses. PMID: 26729809
    18. concluded that TLR-1 rs4833095 and TLR10 rs10004195 confer susceptibility to development of gastroduodenal disease, especially GC in H.pylori disease PMID: 26559190
    19. SNP TLR1-248N is associated with TB protection in an Indian population and exhibits an increased immune response to Mycobacterium tuberculosis lysate in vitro. PMID: 25857934
    20. T1805G genotype associated with reduced risk of Bacillus Calmette-Guerin osteitis following infant vaccination PMID: 25605403
    21. The expression of TLR1 was the lowest and expression of TLR4 was the highest on leukocytes in acute otitis media children. PMID: 24629739
    22. Toll-like receptor 1 Gene SNP rs5743618 is associated with increased risk for tuberculosis in Han Chinese children. PMID: 25544311
    23. TLR1 rs4833095 and TLR10 rs10004195 may play crucial roles in H. pylori susceptibility and gastric pathogenesis. PMID: 25687912
    24. Data suggest that the TLR2 Arg753Gln and TLR1 Ile602Ser SNPs influence the risk of developing leptospirosis and its severity. PMID: 25784560
    25. Frequencies of TLR1-TLR6 two-locus haplotypes in major populations of South Urals were determined for the first time. PMID: 26470427
    26. Polymorphisms in TLR1 (R80T), NOD2 (L1007fsX1), and MYD88 (-938C>A) are associated with predisposition to development of chronic Q fever. PMID: 25722298
    27. Expression of toll-like receptors 1-5 but not TLR 6-10 is elevated in livers of patients with non-alcoholic fatty liver disease. PMID: 24351080
    28. rs4833095 of TLR1 may be associated with the susceptibility for alopecia areata in the Korean population PMID: 24780078
    29. Genetic variation rs5743565 in TLR1 might be associated with the decreased susceptibility to Graves disease, whlie polymorphisms in TLR6 and TLR10 did not reach the statistical significance. PMID: 25028161
    30. These results clarify the importance of TLR2/1 and FcgammaRII in platelet adhesion and activation, and strengthen the role of platelets as an active player in sensing bacterial infections. PMID: 25553878
    31. The correlation between TLR1, TLR6, and TLR10 polymorphisms and the development of atopic dermatitis in the Republic of Bashkortostan has been found. PMID: 25850295
    32. SNPs in the exons of TLR1 and TLR6 are associated with susceptibility to type 1 diabetes in the Chinese population. PMID: 25261617
    33. Data show that a total of nine single-nucleotide polymorphisms (SNPs) in TLR1, TLR4, TLR6 and TLR8 in Caucasians, and two other SNPs, one each in Toll-like receptors TLR4 and TLR8, in African Americans were significantly associated with HIV status. PMID: 25253287
    34. T1805G polymorphism not associated with severity of bronchiolitis or risk of postbronchiolitis wheezing PMID: 24112285
    35. No association was observed for either TLR1 1805 T>G or TLR6 745 C>T polymorphism and pulmonary tuberculosis. PMID: 24984237
    36. A common TLR1 polymorphism (T-->G mutation at position 1805) is associated with an increased risk of laboratory-defined neurosyphilis PMID: 24922103
    37. TLR1 polymorphisms could influence immune-related disease through Teff resistance to Treg suppression. PMID: 25378593
    38. This review summarizes current knowledge of the multiple roles of toll-like receptors in bacterial lung infections and highlights the mechanisms used by pathogens to modulate or interfere with TLR signaling in the lungs. PMID: 25033332
    39. TLR2 and its co-receptors, TLR1 and TLR6, contribute to the pathogenicity of aPLA; aPLA are internalized via clathrin- and CD14-dependent endocytosis; and endocytosis is required for NF-kappaB activation PMID: 24612386
    40. s demonstrated that TLR1 rs5743618 was associated with asthma and atopic eczema during the first 6 years of life after early bronchiolitis and TLR6 rs5743810 was associated with present atopy at preschool age. PMID: 24445834
    41. TLR1 expression in periprosthetic tissues most accurately predicted periprosthetic joint infection. PMID: 25320195
    42. the genetic architecture of TLR1 variation differs substantially in southeast Asians compared to other populations and common variation in TLR1 in Thais is not associated with outcome from melioidosis. PMID: 24392083
    43. Data indicate that single nucleotide polymorphism of toll-like receptor TLR1 was significantly associated with a reduced risk of coronary artery disease (CAD). PMID: 25128583
    44. Four genes showed increased expression in the epithelium of OLP patients: CD14, CXCL1, IL8, and TLR1, and at least two of these proteins, TLR1 and CXCL1, were expressed at substantial levels in oral keratinocytes. PMID: 24581860
    45. Interestingly, 602Ser, which shows signatures of selection, inhibits TLR1 surface trafficking and subsequent activation of NFkappaB upon recognition of a ligand. This suggests that reduced TLR1 activity may be beneficial for human health. PMID: 24002163
    46. Toll like receptor 1 single nucleotide polymorphism I602S may play a role in the pathogenesis of M. abscessus lung infection in patients with cystic fibrosis. PMID: 23403223
    47. Triggering the TLR2/1 complex with Pam3CSK4 initiates human platelet activation by engaging tyrosine kinases of the src family and Syk, the adaptor protein LAT, as well as the key mediator PLCgamma2. PMID: 24240055
    48. In the genetic association analysis, polymorphisms in TLR1 (S248N and R80T), TLR2 (P631H), and TLR6 (P249S) were associated with an increased susceptibility to complicated skin and skin structure infections. PMID: 24511099
    49. These results suggest that TLR2/1 signaling and S1P cooperate in pro-inflammatory cytokine production and myofibroblast differentiation and promote cell migration of skin fibroblast PMID: 24440818
    50. Genetic variation in TLR1 is associated with increased mortality in patients with sepsis after traumatic injury. PMID: 23478521

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Golgi apparatus.
  • 蛋白家族：
    Toll-like receptor family
  • 组织特异性：
    Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.
  • 数据库链接：

    HGNC: 11847

    OMIM: 601194

    KEGG: hsa:7096

    STRING: 9606.ENSP00000354932

    UniGene: Hs.621817