TMBIM1 Antibody
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) TMBIM1 Polyclonal antibody
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Uniprot No.:Q969X1
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基因名:TMBIM1
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别名:TMBIM1; LFG3; RECS1; PP1201; PSEC0158; Protein lifeguard 3; Protein RECS1 homolog; Transmembrane BAX inhibitor motif-containing protein 1
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宿主:Rabbit
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反应种属:Human, Mouse
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免疫原:Recombinant Human Protein lifeguard 3 protein (1-109AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,TMBIM1 Antibody (CSB-PA853376LA01HU),的标记方式是Non-conjugated。对于TMBIM1 Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, WB, IF
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推荐稀释比:
Application Recommended Dilution WB 1:1000-1:5000 IF 1:50-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.
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基因功能参考文献:
- The combined analysis identified a new risk association for colorectal cancer (CRC) at 2q35 marked by rs992157 which is intronic to PNKD and TMBIM1.Intriguingly this susceptibility single-nucleotide polymorphism (SNP) is in strong linkage disequilibrium (r(2) = 0.90, D' = 0.96) with the previously discovered GWAS SNP rs2382817 for inflammatory bowel disease (IBD). PMID: 27005424
- TMBIM1 is an effective suppressor of steatohepatitis and a previously unknown regulator of the multivesicular body (MVB)-lysosomal pathway. PMID: 28481357
- These results suggest that the TMBIM family has comparable functions in the maintenance of intracellular Ca(2) homeostasis in a wide variety of tissues PMID: 25764978
- data suggest that PP1201 functions as an anti-apoptotic protein and its increased expression in vascular cells can contribute to homeostasis by reducing Fas trafficking to the cell membrane PMID: 21107705
- The tmbim1 may participate in cell death regulation by interacting with proteins of Bcl-2 family, promoting tumor metastasis, which is deduced from the evolutionary conservation of the membrane protein family containing multiple membrane spanning segments PMID: 18440869
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亚细胞定位:Membrane; Multi-pass membrane protein. Lysosome membrane. Endosome membrane.
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蛋白家族:BI1 family, LFG subfamily
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数据库链接:
HGNC: 23410
OMIM: 610364
KEGG: hsa:64114
STRING: 9606.ENSP00000258412
UniGene: Hs.591605