TMED2 Antibody
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货号:CSB-PA795013
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规格:¥1100
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图片:
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其他:
产品详情
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Uniprot No.:Q15363
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基因名:TMED2
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别名:coated vesicle membrane protein antibody; Membrane protein p24A antibody; p24 antibody; p24 family protein beta-1 antibody; P24A antibody; p24beta1 antibody; RNP24 antibody; Sid 394 antibody; Sid394 antibody; TMED2 antibody; TMED2_HUMAN antibody; transmembrane emp24 domain trafficking protein 2 antibody; Transmembrane emp24 domain-containing protein 2 antibody
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宿主:Rabbit
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反应种属:Human,Mouse,Rat
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免疫原:Fusion protein of Human TMED2
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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抗体亚型:IgG
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纯化方式:Antigen affinity purification
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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产品提供形式:Liquid
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应用范围:ELISA,WB,IHC
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推荐稀释比:
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 IHC 1:25-1:100 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like micro...显示更多
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基因功能参考文献:
- Surface plasmon resonance and solution NMR analyses revealed that p24beta1 and p24delta1 GOLD domains interact weakly (Kd= ~10(-4)M). PMID: 27569046
- TMED2/p24beta1 is expressed in all gestational stages of human placentas and in choriocarcinoma cell lines. PMID: 22212250
- Both p24A transmembrane protein and p23 are specific cargo receptors of G protein-coupled receptors (GPCR) and differentially regulate GPCR signaling in astrocytes. PMID: 21219331
- These results suggest that p24A is the limiting factor in CaSR trafficking in the early secretory pathway, and that cycling between the ER and ERGIC protects CaSR from degradation. PMID: 20361938
- p24A is a regulator of signal-dependent trafficking that controls ARF1-dependent resensitization of PAR-2 PMID: 17693410
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亚细胞定位:Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein.
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蛋白家族:EMP24/GP25L family
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数据库链接:
HGNC: 16996
KEGG: hsa:10959
STRING: 9606.ENSP00000262225
UniGene: Hs.733403