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TMEM14A Antibody

  • 货号：
    CSB-PA023720LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA023720LA01HU diluted at 1:350 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA023720LA01HU diluted at 1:350 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Western blot
      All lanes: TMEM14A antibody at 0.8µg/ml + PC-3 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 11 kDa
      Observed band size: 11 kDa
    • Immunofluorescent analysis of PC-3 cells using CSB-PA023720LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TMEM14A Polyclonal antibody
  • Uniprot No.：
    Q9Y6G1
  • 基因名：
    TMEM14A
  • 别名：
    TMEM14A; C6orf73; PTD011; Transmembrane protein 14A
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Transmembrane protein 14A protein (45-78AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TMEM14A Antibody (CSB-PA023720LA01HU)，的标记方式是Non-conjugated。对于TMEM14A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA023720LB01HU TMEM14A Antibody, HRP conjugated ELISA
    FITC CSB-PA023720LC01HU TMEM14A Antibody, FITC conjugated
    Biotin CSB-PA023720LD01HU TMEM14A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.
  • 基因功能参考文献：
    1. these results indicate that TMEM14A has a pro-tumorigenic effect in ovarian cancer cells, suggesting an important role of this protein in ovarian cancer oncogenesis and metastasis. PMID: 26896463
    2. findings show for the first time that TMEM14A inhibits apoptosis by blocking the mitochondrial permeability transition and stabilizing mitochondrial membrane potential PMID: 21723035
  • 亚细胞定位：
    Mitochondrion membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane.
  • 蛋白家族：
    TMEM14 family
  • 组织特异性：
    Expressed at significantly higher levels in ovarian cancer tissues than in normal tissues (at protein level).
  • 数据库链接：

    HGNC: 21076

    KEGG: hsa:28978

    UniGene: Hs.94896