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TMEM9 Antibody

  • 货号：
    CSB-PA023894LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA023894LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA023894LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品描述：

    CUSABIO generates the TMEM9 antibody by immunizing rabbits with the recombinant human TMEM9 (111-183AA). The resulting antibody is a polyclonal antibody and occurs as an unconjugated IgG. It is purified by protein G and reaches up to 95% in purity. And it is only reactive with human TMEM9 protein, which facilitates v-ATPase (vacuolar adenosine triphosphatase) assembly for vesicular acidification and lysosomal protein degradation. Studies have shown that TMEM9 hyperactivates Wnt signaling for liver regeneration and tumorigenesis through lysosomal degradation of APC. This TMEM9 antibody is suitable for the detection of the TMEM9 protein in ELISA and IHC analyses.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TMEM9 Polyclonal antibody
  • Uniprot No.：
    Q9P0T7
  • 基因名：
    TMEM9
  • 别名：
    TMEM9 antibody; DERP4 antibody; TMEM9A antibody; HSPC186 antibody; PSEC0012 antibody; UNQ631/PRO1248 antibody; Transmembrane protein 9 antibody; Dermal papilla-derived protein 4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Transmembrane protein 9 protein (111-183AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TMEM9 Antibody (CSB-PA023894LA01HU)，的标记方式是Non-conjugated。对于TMEM9 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA023894LB01HU TMEM9 Antibody, HRP conjugated ELISA
    FITC CSB-PA023894LC01HU TMEM9 Antibody, FITC conjugated
    Biotin CSB-PA023894LD01HU TMEM9 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking. By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation. TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC. In the liver, involved in hepatic regeneration.
  • 基因功能参考文献：
    1. TMEM9 plays a significant role in TNF-alpha-enhanced cytokines (IL-6 and IL-1beta) secretion in LX-2 cells and that the canonical Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. PMID: 30119033
    2. TMEM9 knockdown by RNA interference resulted in G1 arrest. PMID: 27220462
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    4. phylogenetically conserved, widely expressed transmembrane protein with a potential, but unknown function in intracellular transport that localizes to lysosomes and late endosomes PMID: 12359240
    5. TMEM9B is a key component of inflammatory signaling pathways and suggest that endosomal or lysosomal compartments regulate these pathways PMID: 18541524

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  • 亚细胞定位：
    Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Endosome, multivesicular body membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    TMEM9 family
  • 组织特异性：
    Highly expressed in adrenal gland, thyroid gland, testis, ovary and prostate. Moderate expression in trachea, spinal cord, stomach, colon, small intestine and spleen. Low expression in bone marrow, lymph node, thymus and peripheral blood lymphocytes. Expr
  • 数据库链接：

    HGNC: 18823

    OMIM: 616877

    KEGG: hsa:252839

    STRING: 9606.ENSP00000356298

    UniGene: Hs.181444