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TMSB10 Antibody

  • 货号：
    CSB-PA274264
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA274264(TMSB10 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P63313
  • 基因名：
    TMSB10
  • 别名：
    MIG 12 antibody; MIG12 antibody; Migration inducing gene 12 antibody; Migration inducing protein 12 antibody; Ptmb10 antibody; TB 10 antibody; TB10 antibody; Thyb 10 antibody; Thyb10 antibody; Thymosin beta-10 antibody; Tmsb10 antibody; TYB10_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human TMSB10
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:30-1:150
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
  • 基因功能参考文献：
    1. TMSB10 may hold promise as a minimally invasive serum cancer biomarker for the diagnosis of breast cancer and a potential therapeutic target which will facilitate the development of a novel therapeutic strategy against breast cancer. PMID: 28179017
    2. High expression of thymosin beta 10 is associated with hepatocellular carcinoma. PMID: 25037578
    3. High expression levels of TMSB10 correlated with lymphatic metasttases in papillary thyroid carcinoma, especially in the central neck region. PMID: 24974154
    4. Regarding HCC, Tbeta4 reactivity was detected in 7/23 cases (30%) and Tbeta10 reactivity in 22/23 (97%) cases analyzed, adding HCC to human cancers that express these beta-thymosins. PMID: 24704991
    5. Low expression of Tbeta10 is associated with metastatic phenotype of CCA in vitro and in vivo. PMID: 24053380
    6. The results show, for the first time, a strong expression of thymosin beta 10 in the human salivary glands during the initial phases of the physiological development, present at the 13th week of gestation, and suggesting a role for the peptide in the salivary glands' organogenesis. PMID: 21733645
    7. Thymosin beta10 expression driven by the human TERT promoter induces ovarian cancer-specific apoptosis through ROS production. PMID: 22623951
    8. Amplification of thymosin beta 10 is associated with metastatic and aggressive papillary thyroid carcinomas. PMID: 22161024
    9. hypomethylation of the promoter is not associated with its overexpression in non-small cell lung cancer PMID: 22038593
    10. Describe beta-thymosins in bronchoalveolar lavage fluid and their possible involvement in the pathogenesis of scleroderma lung disease. PMID: 21314931
    11. The expression of Tbeta10 in the human kidney during the initial phases of its physiological development, mainly restricted in the proximal and the distal tubuli. PMID: 20836742
    12. TB10 plays a critical role in the regulation of anchorage-independent growth and assembly of actin filaments. PMID: 12481941
    13. Introduction of E-Tmod cDNA into a tumor cell line reverses TB10 mediated apoptosis and restored actin architectures. PMID: 14741341
    14. TB10 has a role in progression of human thyroid carcinomas, particularly in the anaplastic histotypes PMID: 15254683
    15. Inhibition of Ras signal transduction by thymosin beta(10) results in antiangiogenic and antitumor effects, suggesting that thymosin beta(10) may be valuable in anticancer therapy. PMID: 15665289
    16. results strongly suggest that Thr20 is specifically required for actin sequestration by TB10 in ovarian cancer cells PMID: 16012174
    17. the distribution of staining for thymosin beta10 was inverse of staining for F-actin. These data support a physiological role for thymosin beta10 in sequestration of G-actin as well as in cancer cell motility. PMID: 16786322
    18. Expression of TB10 and its role in non-small cell lung cancer are reported. PMID: 18789485
    19. Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation. PMID: 19194824
    20. outlines for the first time that salivary glands during foetal life express and secrete peptides such as beta-thymosins probably involved in the development of the oral cavity and its annexes PMID: 19337364

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Thymosin beta family
  • 数据库链接：

    HGNC: 11879

    OMIM: 188399

    KEGG: hsa:9168

    STRING: 9606.ENSP00000233143

    UniGene: Hs.446574