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TNF Antibody

  • 货号：
    CSB-PA023955DA01SH
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Tumor necrosis factor antibody at dilution of 1: 1000
      Lane 1: Tumor necrosis factor protein at 0.05μg
      Lane 2: Tumor necrosis factor protein at 0.5μg
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 26 kDa
      Observed band size: 26 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Sheep TNF Polyclonal antibody
  • Uniprot No.：
    P23383
  • 基因名：
  • 别名：
    TNF antibody; TNFA antibody; TNFSF2 antibody; Tumor necrosis factor antibody; Cachectin antibody; TNF-alpha antibody; Tumor necrosis factor ligand superfamily member 2 antibody; TNF-a) [Cleaved into: Tumor necrosis factor antibody; membrane form antibody; N-terminal fragment antibody; NTF); Intracellular domain 1 antibody; ICD1); Intracellular domain 2 antibody; ICD2); C-domain 1; C-domain 2; Tumor necrosis factor antibody; soluble form] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Sheep
  • 免疫原：
    Recombinant Sheep Tumor necrosis factor protein (78-234AA)
  • 免疫原种属：
    Sheep
  • 标记方式：
    Non-conjugated

    本页面中的产品，TNF Antibody (CSB-PA023955DA01SH)，的标记方式是Non-conjugated。对于TNF Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA023955DB01SH TNF Antibody, HRP conjugated ELISA
    FITC CSB-PA023955DC01SH TNF Antibody, FITC conjugated
    Biotin CSB-PA023955DD01SH TNF Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.; The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
  • 基因功能参考文献：
    1. The aim of the study was to assess the prognostic significance of Tumor Necrosis Factor-alpha, Interleukin-12(p40), Interleukin-6 and Interleukin 10 levels in cerebrospinal fluid (CSF) in sheep with encephalitic listeriosis. PMID: 25817420
    2. The p38 MAPK inhibitor decreased (P < 0.01) gene expression of TNFa but its effect was not observed at the level of TNFa protein synthesis PMID: 24995301
    3. TNF-alpha gene expression in multifidus was greater on both sides in the disc lesion animals than in the muscle of control animals. PMID: 24718080
    4. Injection of peptidoglycan-polysaccharide resulted in fever, increased concentrations of TNF-alpha on the day of and the day after challenge, and decreased concentrations of progesterone on days 14 and 21. PMID: 20603027
    5. These data are consistent with the effects of LPS on GH secretion originating through peripheral cytokine presentation to the pituitary, as well as a potential to act directly on selective populations of pituitary cells via CD14. PMID: 15899940
    6. plasma IL-1 beta, TNF-alpha and MCP-1 may potentially serve as markers to monitor prognosis of pregnancy toxaemia in ewes PMID: 17221363

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein.; [Tumor necrosis factor, membrane form]: Membrane; Single-pass type II membrane protein.; [Tumor necrosis factor, soluble form]: Secreted.; [C-domain 1]: Secreted.; [C-domain 2]: Secreted.
  • 蛋白家族：
    Tumor necrosis factor family
  • 数据库链接：

    KEGG: oas:443540

    UniGene: Oar.455