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TNFAIP1 Antibody

  • 货号：
    CSB-PA004307
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HuvEc cells using TNF-IP 1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q13829
  • 基因名：
    TNFAIP1
  • 别名：
    TNFAIP1 antibody; BACURD2 antibody; EDP1BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 antibody; hBACURD2 antibody; BTB/POZ domain-containing protein TNFAIP1 antibody; Protein B12 antibody; Tumor necrosis factor antibody; alpha-induced protein 1 antibody; endothelial antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human TNF-IP 1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.
  • 基因功能参考文献：
    1. TNFAIP1 silence significantly increased the migrated and invaded cells compared to that in control, while these increases were abolished by miR-424 suppression. PMID: 28535539
    2. CREB is a negative regulator of the TNFAIP1 gene. PMID: 26398148
    3. TNFAIP1 plays an important role in mediating miR-15a dependent biological functions in osteosarcoma. PMID: 26261520
    4. MiR-181a played a critical role in regulating pancreatic cancer growth and migration, likely interacting with TNFAIP1. PMID: 26152285
    5. Results showed that the expression of TNFAIP1 protein was significantly increased in osteosarcoma tissues and associated with distant metastasis. PMID: 24969828
    6. Expression of TNFAIP1 is regulated by the transcriptional factor Sp1. PMID: 23912453
    7. TNFAIP1 inhibited the transcriptional activities of nuclear factor kappa B (NF-kappaB) and activating protein-1 reporters PMID: 22810651
    8. CK2 could phosphorylate TNFAIP1 in vitro and in vivo, which facilitated the distribution of TNFAIP1 in nucleus and enhanced its interaction with PCNA. PMID: 19851886
    9. The promoter region of human TNFAIP1 gene was functionally characterized. PMID: 19593659
    10. suggest that the TNFAIP1/POLDIP2 complex sense-antisense architecture represents a clinically significant transcriptional structural-functional gene module associated with amplification of the genomic region on 17q11.2 in breast cancer. PMID: 20158880
    11. TNFAIP1 shows increased transcript levels in Alzheimer's disease brains PMID: 12600716
    12. Expression levels of TNFAIP1 are high in COS7 and NIH3T3 cell lines but low in the cancer cell lines. PMID: 16870576

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Endosome. Note=Colocalizes with RHOB in endosomes.
  • 蛋白家族：
    BACURD family
  • 数据库链接：

    HGNC: 11894

    OMIM: 191161

    KEGG: hsa:7126

    STRING: 9606.ENSP00000226225

    UniGene: Hs.76090