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TNKS2 Antibody

  • 货号：
    CSB-PA867136LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA867136LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA867136LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA867136LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA867136LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TNKS2 Polyclonal antibody
  • Uniprot No.：
    Q9H2K2
  • 基因名：
    TNKS2
  • 别名：
    ADP-ribosyltransferase diphtheria toxin-like 6 antibody; ARTD6 antibody; PARP 5b antibody; PARP 5c antibody; PARP-5b antibody; PARP-5c antibody; PARP5B antibody; PARP5C antibody; pART6 antibody; Poly [ADP ribose] polymerase 5B antibody; Poly [ADP-ribose] polymerase 5B antibody; TANK2 antibody; Tankyrase 2 antibody; Tankyrase II antibody; Tankyrase like protein antibody; Tankyrase related protein antibody; Tankyrase TRF1 interacting ankyrin related ADP ribose polymerase 2 antibody; Tankyrase-2 antibody; Tankyrase-like protein antibody; Tankyrase-related protein antibody; TNKL antibody; TNKS 2 antibody; TNKS-2 antibody; TNKS2 antibody; TNKS2_HUMAN antibody; TRF1 Interacting Ankyrin Related ADP ribose polymerase 2 antibody; TRF1-interacting ankyrin-related ADP-ribose polymerase 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Tankyrase-2 protein (1-246AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TNKS2 Antibody (CSB-PA867136LA01HU)，的标记方式是Non-conjugated。对于TNKS2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA867136LB01HU TNKS2 Antibody, HRP conjugated ELISA
    FITC CSB-PA867136LC01HU TNKS2 Antibody, FITC conjugated
    Biotin CSB-PA867136LD01HU TNKS2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. Stimulates 26S proteasome activity.
  • 基因功能参考文献：
    1. CTIF was identified as a novel PARylation target of the TNKS2 in the centrosomal region of cells, which plays a role in the distribution of the centrosomal satellites. PMID: 29789535
    2. Either tankyrase 1 or 2 is sufficient to maintain telomere length, but both are required to resolve telomere cohesion and maintain mitotic spindle integrity. Tankyrases are required for Notch2 to exit the plasma membrane and enter the nucleus to activate transcription. PMID: 29263426
    3. Finally, through functional validation, we uncovered a role for TNKS/2 in peroxisome homeostasis and determined that this function is independent of TNKS enzyme activities. PMID: 28723574
    4. Polymerization is required for Tankyrase to drive beta-catenin-dependent transcription. The polymeric state supports PARP activity and allows Tankyrase to effectively access destruction complexes through enabling avidity-dependent AXIN binding. PMID: 27494558
    5. These structural insights will be invaluable for the functional and biophysical characterization of TNKS1/2, including the role of TNKS oligomerization in protein poly(ADP-ribosyl)ation (PARylation) and PARylation-dependent ubiquitylation. PMID: 27328430
    6. High TNKS2 expression is associated with breast cancer. PMID: 27485113
    7. The tumor suppressive activity of miR-490-3p is largely mediated through downregulation of TNKS2 and inactivation of beta-catenin signaling. Thus, miR-490-3p may represent a potential therapeutic target for triple-negative breast cancer. PMID: 27506313
    8. Data show that E7449 represents a dual Poly(ADP-ribose) Polymerase 1/2 and tankyrase 1/2 inhibitor which has the advantage of targeting Wnt/beta-catenin signaling addicted tumors. PMID: 26513298
    9. rs1340420 SNP was associated with lower NSCLC risk, whereas rs1770474 SNP was associated with higher squamous-cell carcinoma risk PMID: 26293798
    10. Tankyrase inhibition is a potential therapeutic approach for treating a subgroup HCC with aberrant WNT/beta-catenin signaling pathway. PMID: 26246473
    11. TNKS2 is recruited to DNA lesions by MDC1 and promotes homologous recombination in response to DNA double strand breaks. PMID: 26845027
    12. The variability of genes encoding for TERF1 and TNKS2 is important for keeping the integrity of the telomere structure and show a significant association with longevity. PMID: 25631672
    13. Studies show a significant interaction of IWR1 with acidic and polar residues (Asp and Tyr) in the hydrophobic region at the induced pocket of TNKS1/TNKS2. These two residues are the key for the mechanism of inhibition of TNKS proteins. PMID: 24291818
    14. Data indicate a basis for development of flavones as tankyrase inhibitors and suggest the development of other structurally related inhibitors. PMID: 24116873
    15. Data suggest that miR-20a can promote migration and invasion of cervical cancer cells through the upregulation of TNKS2. PMID: 22449978
    16. Study reports crystal structures of a representative ankyrin repeat clusters of TNKS2 bound to targeting peptides from six substrates. PMID: 22153077
    17. RNF146 RING-type ubiquitin E3 ligase as a positive regulator of Wnt signaling that operates with tankyrase to maintain low steady-state levels of Axin proteins PMID: 21799911
    18. TNKS2 bound to Epstein-Barr virus origin of plasmid replication in coimmunoprecipitation experiments with transfected cell lysates. PMID: 15795250
    19. pathologic overexpression of tankyrase 2 in some tumors may be a result of the cancer-related adaptation of the malignant cells dependent on tankyrase activity. PMID: 16151859
    20. TNKL and TNKS are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients PMID: 18026951
    21. pH dependence and kinetic study of the enzyme activity of tankyrase 2. PMID: 18393764

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  • 亚细胞定位：
    Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus. Chromosome, telomere. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1.
  • 组织特异性：
    Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma,
  • 数据库链接：

    HGNC: 15677

    OMIM: 607128

    KEGG: hsa:80351

    STRING: 9606.ENSP00000360689

    UniGene: Hs.329327