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TNMD Antibody

  • 货号：
    CSB-PA024007LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse heart tissue
      All lanes: TNMD antibody at 2.8μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 38, 24, 31 kDa
      Observed band size: 38 kDa
    • Immunofluorescent analysis of HepG2 cells using CSB-PA024007LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品描述：

    The TNMD antibody is designed to recognize the TNMD proteins from human and mouse samples. When a rabbit received an injection of the recombinant human TNMD protein (131-254aa), an immune response occurred in the rabbit producing large amounts of antibodies against the TNMD protein. The rabbit's blood was collected and isolated to get the anti-serum, which underwent protein G purification to obtain the TNMD polyclonal antibody (purity 95%+). This TNMD antibody has accessed its specificity in ELISA, WB, and IF applications.

    TNMD is known to promote tenocyte differentiation and inhibit their proliferation, which is essential for the proper development and maintenance of tendons and ligaments. TNMD also has anti-angiogenic properties, which are important in preventing the excessive growth of blood vessels and are detrimental to tendon and ligament healing.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TNMD Polyclonal antibody
  • Uniprot No.：
    Q9H2S6
  • 基因名：
    TNMD
  • 别名：
    BRICD4 antibody; BRICHOS domain containing 4 antibody; CHM1 LIKE antibody; ChM1L antibody; Chondromodulin I like antibody; Chondromodulin I like protein antibody; Chondromodulin-1-like protein antibody; Chondromodulin-I-like protein antibody; hChM1L antibody; hTeM antibody; Myodulin antibody; TeM antibody; Tendin antibody; Tenomodulin antibody; Tenomodulin protein antibody; Tnmd antibody; TNMD_HUMAN antibody; UNQ771/PRO1565 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Tenomodulin protein (131-254AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TNMD Antibody (CSB-PA024007LA01HU)，的标记方式是Non-conjugated。对于TNMD Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA024007LB01HU TNMD Antibody, HRP conjugated ELISA
    FITC CSB-PA024007LC01HU TNMD Antibody, FITC conjugated
    Biotin CSB-PA024007LD01HU TNMD Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be an angiogenesis inhibitor.
  • 基因功能参考文献：
    1. our study demonstrates that Tnmd is required for proper tendon tissue adaptation to endurance running and aids in better understanding of the structural-functional relationships of tendon tissues. PMID: 28566251
    2. TNMD is upregulated in adipose tissue of insulin-resistant versus insulin-sensitive individuals. TNMD expression increases in human preadipocytes during differentiation, whereas silencing TNMD blocks adipogenesis. PMID: 26880110
    3. results suggest that Tnmd acts on the maturation or maintenance of the PDL by positively regulating cell adhesion via its BRICHOS domain PMID: 23593173
    4. Report differential expression and cellular localization of novel isoforms of the tendon biomarker tenomodulin and suggest possible roles in tenocyte proliferation and tendon injury. PMID: 22700804
    5. According to these results the sequence variation of TNMD is not associated with alzheimer disease, but might modify the effect of APOE epsilon4-allele in women. PMID: 19524323
    6. Polymorphisms are associated with adiposity and also with glucose metabolism and conversion from glucose intolerance to type 2 diabetes. PMID: 17495183
    7. Tenomodulin is expressed abundantly in the elastin-rich subendothelial outer layer of the normal chordae tendineae cordis. PMID: 18838562
    8. TNMD could be a novel candidate gene for age-related macular degeneration. PMID: 19381347
    9. Human adipose tissue TNMD gene expression is highly affected by obesity, adipose tissue location, and weight loss, indicating that TNMD may play a role in adipose tissue function. PMID: 19602561

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  • 亚细胞定位：
    [Isoform 1]: Membrane; Single-pass type II membrane protein. Nucleus envelope.; [Isoform 2]: Membrane; Single-pass type II membrane protein. Nucleus envelope.; [Isoform 3]: Cytoplasm.
  • 蛋白家族：
    Chondromodulin-1 family
  • 组织特异性：
    Highly expressed in hypovascular connective tissues such as tendons. Has also strong expression in adipose tissue.
  • 数据库链接：

    HGNC: 17757

    OMIM: 300459

    KEGG: hsa:64102

    STRING: 9606.ENSP00000362122

    UniGene: Hs.132957