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TNPO2 Antibody

  • 货号：
    CSB-PA024021GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O14787
  • 基因名：
    TNPO2
  • 别名：
    Importin 3 antibody; IPO3 antibody; Karyopherin beta 2b, transportin antibody; Karyopherin beta-2b antibody; KPNB2B antibody; Tnpo2 antibody; TNPO2_HUMAN antibody; Transportin 2 (importin 3, karyopherin beta 2b) antibody; Transportin 2 (Importin 3, karyopherin beta 2b), isoform CRA b antibody; Transportin 2 antibody; Transportin-2 antibody; TRN2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TNPO2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
  • 基因功能参考文献：
    1. IPO3 binds NEMO, promotes its nuclear import, and is critical for DNA damage-dependent NF-kappaB activation. PMID: 26060253
    2. Studies indicate potential roles of Tranportin-1 and Transportin-2 beyond protein nuclear import. PMID: 24780099
    3. a role for the nuclear trafficking factor TRN2 (transportin 2) through HuR in cell death PMID: 21646354
    4. Nuclear import of fused in sarcoma (FUS) is dependent on Transportin, and interference with this transport pathway leads to cytoplasmic redistribution and recruitment of fused in sarcoma (FUS) into stress granules. PMID: 20606625
    5. Karyopherin beta 2B participates in mRNA export from the nucleus PMID: 12384575
    6. Transportin-2 mediates nuclear import of HuR protein in vitro PMID: 14981248
    7. The structure of Kap beta 2 (also known as Transportin) bound to one of its substrates, the NLS of hnRNP A1, that we report here explains the mechanism of substrate displacement by Ran GTPase. PMID: 16901787

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Importin beta family, Importin beta-2 subfamily
  • 数据库链接：

    HGNC: 19998

    OMIM: 603002

    KEGG: hsa:30000

    STRING: 9606.ENSP00000407182

    UniGene: Hs.416049