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TNRC6C Antibody

  • 货号：
    CSB-PA862070LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate
      All lanes: TNRC6C antibody at 3.4μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 176, 180 kDa
      Observed band size: 176 kDa
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA862070LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TNRC6C Polyclonal antibody
  • Uniprot No.：
    Q9HCJ0
  • 基因名：
    TNRC6C
  • 别名：
    KIAA1582 antibody; TNR6C_HUMAN antibody; TNRC 6C antibody; Tnrc6c antibody; Trinucleotide repeat containing 6C antibody; Trinucleotide repeat containing gene 6C protein antibody; Trinucleotide repeat-containing gene 6C protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Trinucleotide repeat-containing gene 6C protein (157-421AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TNRC6C Antibody (CSB-PA862070LA01HU)，的标记方式是Non-conjugated。对于TNRC6C Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA862070LB01HU TNRC6C Antibody, HRP conjugated ELISA
    FITC CSB-PA862070LC01HU TNRC6C Antibody, FITC conjugated
    Biotin CSB-PA862070LD01HU TNRC6C Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
  • 基因功能参考文献：
    1. These findings reveal that despite species-specific differences in the relative strength of the PABPC1-binding sites, the interaction between GW182 proteins and PABPC1 is critical for miRNA-mediated silencing in animal cells. PMID: 21063388
    2. The s show that a conserved motif in the human GW182 paralog TNRC6C interacts with the C-terminal domain of polyadenylate binding protein 1 (PABC) and present the crystal structure of the complex. PMID: 20098421
    3. Through deletion and mutagenesis, study identified the C-terminal part of TNRC6C encompassing the RRM RNA-binding motif as a key effector domain mediating protein synthesis repression by TNRC6C. PMID: 19304925
    4. Our findings indicate that TNRC6C, is recruited to miRNA targets through an interaction between their N-terminal domain and an Argonaute protein PMID: 19383768
  • 蛋白家族：
    GW182 family
  • 数据库链接：

    HGNC: 29318

    OMIM: 610741

    KEGG: hsa:57690

    STRING: 9606.ENSP00000336783

    UniGene: Hs.406810