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TOMM34 Antibody

  • 货号：
    CSB-PA623014DSR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA623014DSR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA623014DSR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TOMM34 Polyclonal antibody
  • Uniprot No.：
    Q15785
  • 基因名：
    TOMM34
  • 别名：
    hTom34 antibody; HTOM34P antibody; Mitochondrial import receptor subunit TOM34 antibody; OTTHUMP00000031079 antibody; Outer mitochondrial membrane translocase (34kD) antibody; TOM 34 antibody; TOM34 antibody; TOM34_HUMAN antibody; TOMM 34 antibody; TOMM34 antibody; Translocase of outer membrane 34 kDa subunit antibody; Translocase of outer mitochondrial membrane 34 antibody; URCC 3 antibody; URCC3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Mitochondrial import receptor subunit TOM34 protein (1-309AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.
  • 基因功能参考文献：
    1. Data show that Tomm34 extensively interacts with the C-terminal structures of Hsp70 selectively in its ATP-bound state and that this interaction is strongly entropically driven. PMID: 26944342
    2. These results suggest that Tomm34 represents a novel scaffolding co-chaperone of Hsp70 and Hsp90, which may facilitate Hsp70/Hsp90 cooperation during protein folding PMID: 24567332
    3. TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome. PMID: 23053644
    4. Results identify Tom34 as a cochaperone of Hsp70/Hsp90 in mitochondrial protein import. PMID: 22178133
    5. Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins PMID: 11913975
    6. Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol PMID: 11913976
    7. TOMM34 is involved in the growth of colon cancer cells PMID: 16820880
    8. Data show that NRF-1 is the main transcription factor regulating the expression of TOMM34, and that Sp1 interacts with NRF-1 to stimulate the promoter's full activity. PMID: 18364745

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  • 亚细胞定位：
    Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Tom34 family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 15746

    OMIM: 616049

    KEGG: hsa:10953

    STRING: 9606.ENSP00000361900

    UniGene: Hs.517066