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TRAF3IP3 Antibody

  • 货号：
    CSB-PA896865LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse brain tissue, Rat heart tissue, Rat liver tissue
      All lanes: TRAF3IP3 antibody at 2.7μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 64, 62, 41 kDa
      Observed band size: 64, 62, 41 kDa
    • Immunofluorescent analysis of Hela cells using CSB-PA896865LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TRAF3IP3 Polyclonal antibody
  • Uniprot No.：
    Q9Y228
  • 基因名：
    TRAF3IP3
  • 别名：
    TRAF3IP3 antibody; T3JAM antibody; TRAF3-interacting JNK-activating modulator antibody; TRAF3-interacting protein 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human TRAF3-interacting JNK-activating modulator protein (74-185AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TRAF3IP3 Antibody (CSB-PA896865LA01HU)，的标记方式是Non-conjugated。对于TRAF3IP3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA896865LB01HU TRAF3IP3 Antibody, HRP conjugated ELISA
    FITC CSB-PA896865LC01HU TRAF3IP3 Antibody, FITC conjugated
    Biotin CSB-PA896865LD01HU TRAF3IP3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development. Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF. Plays also an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism. Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts. In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production. However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'-dependent ubiquitination of TBK1.
  • 基因功能参考文献：
    1. This paper provides an alignment of the mouse and human proteins. PMID: 14572659
    2. TRAF3IP3 stimulated cell growth by modulating the c-Jun N-terminal kinase (JNK) pathway PMID: 17868742
  • 亚细胞定位：
    Cell membrane. Golgi apparatus membrane; Single-pass type IV membrane protein. Lysosome membrane. Mitochondrion outer membrane.
  • 数据库链接：

    HGNC: 30766

    OMIM: 608255

    KEGG: hsa:80342

    STRING: 9606.ENSP00000355991

    UniGene: Hs.147434